N-terminal pro-brain-type natriuretic peptide: a biochemical surrogate of cardiac function in the potential heart donor☆☆☆

Dronavalli, Vamsidhar B.; Ranasinghe, Aaron; Venkateswaran, Rajamiyer J.; James, Sally; McCabe, Christopher; Wilson, Ian C.; Mascaro, Jorge; Bonser, Robert S.

doi:10.1016/j.ejcts.2010.01.024

Cited by 19 publications

(14 citation statements)

References 28 publications

(37 reference statements)

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“…After brain death, the BNP prohormone is likely synthesized by ventricular myocytes in response to the cardiac wall stress and pressure overload that occur at the time of cerebral injury or brainstem herniation. BNP levels have been shown to be higher in potential heart donors with poor echocardiographic function (36), and NT-proBNP levels closely correlate with indices of cardiac function, by both hemodynamics and echocardiography (37).…”

Section: Donor Biomarkersmentioning

confidence: 99%

Donor selection in the modern era

Khush

2018

Ann. Cardiothorac. Surg.

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The growing disparity between the supply of donor hearts for transplantation and the demand for such organs has led to liberalization of the criteria for donor heart acceptance over the past few decades. The upper age limit and size restrictions for donor heart acceptance continue to be revised and hearts are being routinely used from donors with left ventricular dysfunction, left ventricular hypertrophy (LVH), cocaine use, multiple medical co-morbidities and after cardiopulmonary resuscitation. This article reviews recent data for use of such "expanded criteria" donor hearts and suggests ways to further increase the donor pool, including use of hearts from donors with hepatitis C and after circulatory determination of death. Donor biomarkers and risk scores may eventually aid in heart acceptance decisions, while ethical issues surrounding information sharing with transplant recipients remain a topic of great debate.

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Section: Donor Biomarkersmentioning

confidence: 99%

Donor selection in the modern era

Khush

2018

Ann. Cardiothorac. Surg.

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“…6 One recent study demonstrated that hearts suitable for transplantation at end-optimization of the donor expressed significantly less mRNA encoding for BNP precursors. 18 Less is known about the significance of the donor BNP level and outcome in the allograft recipient. In a small pediatric series (n ϭ 8), cardiac allografts of donors with BNP levels above the upper limit were shown to be acceptable and with a good function after transplantation.…”

Section: Discussionmentioning

confidence: 98%

Donor B-type natriuretic peptide predicts early cardiac performance after heart transplantation

Vorlat

Conraads

Jorens

et al. 2012

The Journal of Heart and Lung Transplantation

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“…In the brain-dead potential heart donor, BNP levels are higher in those hearts with worse echocardiographic function and those unsuitable for transplantation (113). We recently studied NT-proBNP levels in potential heart donors and found that levels closely correlate with indices of cardiac function, both hemodynamic and echocardiographic, and are also predictive of which hearts achieve hemodynamic suitability criteria (114). The likely mechanism of cardiac dysfunction after severe brain injury or brainstem death is excessive myocardial catecholamine release leading to cardiac ischemia (18).…”

Section: B-type Natriuretic Peptide (Bnp) and Nt-probnpmentioning

confidence: 97%

Assessment of the Potential Heart Donor

Dronavalli

Banner

Bonser

2010

Journal of the American College of Cardiology

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Demand for donor hearts exceeds supply, and a significant number of patients die while awaiting transplantation. Within the pool of currently unused potential donor hearts, a proportion may be suitable for transplantation but are declined due to anticipated poor function. Despite current assessment methods, in some donor hearts accepted for transplantation early graft failure develops in the recipient. Current methods of assessment are inadequate, and there is a potential for biomarkers to improve identification of satisfactory hearts for transplantation or hearts destined to fail in the recipient. Biomarkers are routinely used to diagnose and risk-stratify myocardial infarction, acute coronary syndromes, and heart failure. Some of these might facilitate donor heart assessment. Cardiac troponins, cytokines, inflammatory markers, natriuretic peptides, and intracellular proteins may each have discriminant value. This review details the current status of biomarkers in the assessment of donor hearts.

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N-terminal pro-brain-type natriuretic peptide: a biochemical surrogate of cardiac function in the potential heart donor☆☆☆

Cited by 19 publications

References 28 publications

Donor selection in the modern era

Donor selection in the modern era

Donor B-type natriuretic peptide predicts early cardiac performance after heart transplantation

Assessment of the Potential Heart Donor

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