N-terminal pro B-type natriuretic peptide and angiogenic biomarkers in the prognosis of adverse outcomes in women with suspected preeclampsia

Álvarez-Fernández, Indira; Prieto, Belén; Rodríguez, Verónica; Ruano, Yolanda; Escudero, Ana I; Álvarez, Francisco V.

doi:10.1016/j.cca.2016.10.033

Cited by 27 publications

(28 citation statements)

References 38 publications

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“…The vast majority of studies were of prospective cohort design (n=15), except for 2 retrospective cohort studies. 23 , 24 All but one 24 included studies (n=16) had adequately described population selection, tests and measurements used, and outcomes. Fourteen of the studies specified masking of the clinicians to the PlGF test results and the technicians to the adverse outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…Some of these studies on suspected preeclampsia did not report on the prevalence of confirmed HDPs (n=5 studies). 12 , 23 , 24 , 31 , 32 …”

Section: Resultsmentioning

confidence: 99%

“…Among women who were preterm, 9 studies 12 , 23 – 26 , 30 , 31 , 36 , 37 reported on the prediction of earlier delivery (for maternal and fetal considerations) either before 37 weeks (from a median [range] of 32 weeks [30.6–35]; n=7 studies), or within 7 or 14 days of PlGF testing (from a median [range] of 31 weeks [30.6–32]; n=5 studies; Table). Seven of these studies evaluated the use of PlGF alone, 5 studies evaluated the sFlt-1/PlGF ratio, and 2 studies evaluated PlGF/sENG.…”

Section: Resultsmentioning

confidence: 99%

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Placental Growth Factor as a Prognostic Tool in Women With Hypertensive Disorders of Pregnancy

et al. 2017

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Section: Resultsmentioning

confidence: 99%

“…Some of these studies on suspected preeclampsia did not report on the prevalence of confirmed HDPs (n=5 studies). 12 , 23 , 24 , 31 , 32 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Placental Growth Factor as a Prognostic Tool in Women With Hypertensive Disorders of Pregnancy

et al. 2017

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“…Levels of NT-pro-BNP or BNP, which are already used as prognostic factors for cardiovascular diseases, and even for some non-cardiac conditions,8–12 could be potentially used for risk stratification. To the best of our knowledge, Sbarouni et al were the first to apply NT-pro-BNP in aortic dissection.…”

Section: Discussionmentioning

confidence: 99%

“…B-type natriuretic peptide (BNP) is a prohormone secreted by the ventricular myocardium in response to stretching,7 and is used to diagnose and to determine the severity of heart failure. N-terminal pro-BNP (NT-pro-BNP) is a more powerful predictor than BNP and has been reported as a prognostic marker for several conditions 8–12. Previous studies have indicated that patients with acute type A aortic dissection (TAAD) have significantly higher plasma NT-pro-BNP levels compared with controls 13.…”

Section: Introductionmentioning

confidence: 99%

N-terminal pro-B-type natriuretic peptide and outcomes in type B aortic dissection in China: a retrospective multicentre study

et al. 2019

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ObjectivesN-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is an unfavourable factor responsible for poor outcomes in the cardiovascular diseases. Nevertheless, the prognostic role of NT-pro-BNP in type B aortic dissection (TBAD) remains unclear. The aim of the current study was to investigate the relationship between NT-pro-BNP levels and in-hospital and long-term adverse prognosis in patients with TBAD.DesignA retrospective multicentre study.SettingLiutie Central Hospital, Nanfang Hospital and Huiyang Hospital in China.ParticipantsA total of 657 consecutive patients with TBAD were enrolled in the study. NT-pro-BNP was measured at admission and included patients were divided into three groups according to the tertiles of NT-pro-BNP (pg/mL): <95 (n=220), 95–312 (n=218) and >312 (n=219).Primary and secondary outcome measuresLong-term mortality and in-hospital major adverse clinical events.ResultsOverall, in-hospital death occurred in 27 patients (4.1%), which was significantly higher in upper tertiles of NT-pro-BNP (0.5% vs 4.1% vs 7.8%, p<0.001). The incident of in-hospital major adverse clinical events increased along with higher NT-pro-BNP (1.4% vs 11.5% vs 15.5%, p<0.001). NT-pro-BNP >210 pg/mL had 81.5% sensitivity and 58.6% specificity for predicting in-hospital death (area under the curve= 0.774, 95% CI 0.692 to 0.855; p<0.001). After a median of 3.1 years of follow-up, 97 (14.8%) patients died. The Kaplan-Meier analysis indicated that the long-term cumulative mortality was higher in patients with NT-pro-BNP >210 pg/mL compared with patients with NT-pro-BNP ≤210 pg/mL (log-rank=26.92, p<0.001). In multivariable Cox survival modelling, NT-pro-BNP >210 pg/mL was independently associated with long-term death (adjusted HR 2.47, 95% CI 1.45 to 4.22, p=0.001).ConclusionsNT-pro-BNP resulted as an independent predictor of adverse prognosis in patients with TBAD, thus could be used as a potential risk-stratification tool.

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Addition of N‐terminal pro‐B natriuretic peptide to soluble fms‐like tyrosine kinase‐1/placental growth factor ratio > 38 improves prediction of pre‐eclampsia requiring delivery within 1 week: a longitudinal cohort study

Sabrià¹,

Lequerica-Fernández

Lafuente-Ganuza

et al. 2018

Ultrasound in Obstet & Gyne

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N-terminal pro B-type natriuretic peptide and angiogenic biomarkers in the prognosis of adverse outcomes in women with suspected preeclampsia

Cited by 27 publications

References 38 publications

Placental Growth Factor as a Prognostic Tool in Women With Hypertensive Disorders of Pregnancy

Placental Growth Factor as a Prognostic Tool in Women With Hypertensive Disorders of Pregnancy

N-terminal pro-B-type natriuretic peptide and outcomes in type B aortic dissection in China: a retrospective multicentre study

Addition of N‐terminal pro‐B natriuretic peptide to soluble fms‐like tyrosine kinase‐1/placental growth factor ratio > 38 improves prediction of pre‐eclampsia requiring delivery within 1 week: a longitudinal cohort study

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