N-Terminal Pro-B-Type Natriuretic Peptide Is Not a Significant Predictor of Stroke Incidence After 5 Years　― The Ohasama Study ―

Satoh, Michihiro; Murakami, Takahisa; Asayama, Kei; Hirose, Takuo; Kikuya, Masahiro; Inoue, Ryusuke; Tsubota‐Utsugi, Megumi; Murakami, Keiko; Matsuda, Ayako; Hara, Azusa; Obara, Taku; Kawasaki, Ryo; Nomura, Kyoko; Metoki, Hirohito; Node, Koichi; Imai, Yutaka

doi:10.1253/circj.cj-17-1227

Cited by 7 publications

(5 citation statements)

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“…24 The cut-off 55.0 pg/mL was also used in previous studies. 7,23 Given that approximately 60% of the participants had NT-proBNP <55.0 pg/mL ( Supplementary Figure), we used the approximate median NT-proBNP to stratify these participants into 2 groups (NT-proBNP <30.0 pg/mL and ≥30.0 pg/mL). The means and proportions were compared using Student's t-test, chi-squared test, analysis of variance (ANOVA), analysis of covariance (ANCOVA), and multiple logistic regression analysis.…”

Section: Discussionmentioning

confidence: 99%

N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population　― The Ohasama Study ―

et al. 2020

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Brain natriuretic peptide (BNP) and N-terminal pro-Btype natriuretic peptide (NT-proBNP) are secreted from the cardiac ventricles in response to ventricular wall stretch and tension. 4,5 NT-proBNP is increased in heart failure patients and is associated with an increased risk of future cardiovascular disease and all-cause mortality. 4-7 In C hronic kidney disease (CKD) is a major global health burden, and the global incidence and associated mortality have increased over the last several decades. 1 In addition, decreased kidney function is an independent risk factor for cardiovascular disease. 2,3 Therefore, the prevention of CKD is beneficial to public health.

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Section: Discussionmentioning

confidence: 99%

N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population　― The Ohasama Study ―

et al. 2020

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“…On a 12-lead ECG, the PTFV1 may be a useful marker for identifying individuals at a higher risk of future cardiovascular events, particularly in countries where ECGs are commonly performed in the general population. Several studies have shown a significant association between plasma BNP and N-terminal pro-BNP levels and cardiovascular events in the general population [9][10][11][12][13][14]32) . However, the appropriate threshold levels of plasma BNP that indicate an increased risk of future cardiovascular events in the general population with no cardiovascular history remain controversial.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010

Shoji¹,

Kohsaka²,

Sawano³

et al. 2021

JAT

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Aims: P-wave terminal force in lead V1 (PTFV1) is an electrocardiogram marker of increased left atrial pressure and may be a noninvasive and early detectable marker for future cardiovascular events in the general population compared to serum B-type natriuretic peptide (BNP) concentration. The clinical significance of PTFV1 in the contemporary general population is an area of unmet need. We aimed to demonstrate the correlation between PTFV1 and BNP concentrations in a contemporary representative Japanese population.Methods: Among 2,898 adult men and women from 300 randomly selected districts throughout Japan (NIP-PON DATA2010), we analyzed 2,556 participants without cardiovascular disease (stroke, myocardial infarction, and atrial fibrillation). Elevated BNP was defined as a value of ≥ 20 pg/mL based on the definition from the Japanese Circulation Society guidelines. Results:In total, 125 (4.9%) participants had PTFV1. Participants with PTFV1 were older with a higher prevalence of hypertension, major electrocardiographic findings, and elevated BNP concentrations (13.5 [6.9, 22.8] versus 7.8 [4.4, 14.5] pg/mL; P 0.001). After adjustment for confounders, PTFV1 was correlated with elevated BNP (odds ratio, 1.66; 95% confidence interval, 1.05-2.62; P 0.030). This correlation was consistent among various subgroups and was particularly evident in those aged 65 years or those without a history of hypertension. Conclusions:In the contemporary general population cohort, PTFV1 was independently related to high BNP concentration. PTFV1 may be an alternative marker to BNP in identifying individuals at a higher risk of future cardiovascular events in the East Asian population. cause of death worldwide in both men and women 1) . There is considerable evidence that the onset of CVD may be delayed or prevented through interventions

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“…First, the follow-up period was 4.7 years on average, ranging from 0.01 to 7.0 years. However, the Ohasama Study showed that predictive ability decreased at follow-up periods of more than 5 years after NT-proBNP measurement 9 ) . Second, the numbers of lacunar, large-artery occlusive, and embolic stroke cases were small so that further studies are necessary to confirm our findings.…”

Section: Discussionmentioning

confidence: 99%

“…We categorized NT-proBNP into four groups using clinical cutoff points suggested by prior reports 9 , 11 , 22 , 23 ) . Baseline characteristics with respect to NT-proBNP categories were tested using analysis of covariance, and trends of risk factors across NT-proBNP levels were tested by regression analysis.…”

Section: Methodsmentioning

confidence: 99%

Moderate Levels of N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Increased Risks of Total and Ischemic Strokes among Japanese: The Circulatory Risk in Communities Study

Ebihara

Yamagishi

Umesawa

et al. 2020

JAT

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The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases Original Article Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP), frequently used as a biochemical marker for detecting and monitoring heart failure, is also a risk marker for development of coronary heart disease and total stroke. However, studies that explore subtypes of ischemic stroke with regard to NT-proBNP are scarce. Here, we examined NT-proBNP and its impact upon subtypes of ischemic stroke (lacunar stroke, large-artery occlusive stroke and embolic stroke) among Japanese. Methods: We measured NT-proBNP and categorized 4,393 participants of the Circulatory Risk in Communities Study into four groups (55, 55-124, 125-399, and ≥ 400 pg/ml). We used a multivariable Cox proportional hazards model to examine association with risks of stroke and subtypes. Results: During 4.7 years of follow-up, we identified 50 strokes, including 35 ischemic (15 lacunar, 6 largeartery occlusive, 10 embolic strokes) and 14 hemorrhagic strokes. NT-proBNP was associated with stroke risk: the multivariable hazard ratio of total strokes was 7.29 (2.82-18.9) for the highest and 2.78 (1.25-6.16) for the second highest NT-proBNP groups compared with the lowest group. The respective hazard ratios for the highest NT-proBNP group were 9.37 (3.14-28.0) for ischemic stroke and 6.81 (1.11-41.7) for lacunar stroke. Further adjustment for atrial fibrillation did not attenuate these associations. The associations were similarly observed for large-artery occlusive and embolic strokes. Conclusion: We found that even moderate serum levels of NT-proBNP were associated with the risk of total and ischemic strokes among Japanese whose NT-proBNP levels were relatively low compared with Westerners. stretching tension. It is activated by cleavage of the N-terminal, resulting in the formation of brain natriuretic peptide (BNP), an active part, and N-terminal pro-B-type natriuretic peptide (NT-proBNP), an inac

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N-Terminal Pro-B-Type Natriuretic Peptide Is Not a Significant Predictor of Stroke Incidence After 5 Years　― The Ohasama Study ―

Cited by 7 publications

References 29 publications

N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population　― The Ohasama Study ―

N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population　― The Ohasama Study ―

Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010

Moderate Levels of N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Increased Risks of Total and Ischemic Strokes among Japanese: The Circulatory Risk in Communities Study

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N-Terminal Pro-B-Type Natriuretic Peptide Is Not a Significant Predictor of Stroke Incidence After 5 Years ― The Ohasama Study ―

Cited by 7 publications

References 29 publications

N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population ― The Ohasama Study ―

N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population ― The Ohasama Study ―

Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010

Moderate Levels of N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Increased Risks of Total and Ischemic Strokes among Japanese: The Circulatory Risk in Communities Study

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N-Terminal Pro-B-Type Natriuretic Peptide Is Not a Significant Predictor of Stroke Incidence After 5 Years　― The Ohasama Study ―

N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population　― The Ohasama Study ―

N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population　― The Ohasama Study ―