N‐terminal conserved cysteines of Env7 are palmitoylated and direct its stability, localization, and vacuolar fusion regulation in S. cerevisiae (739.12)
Abstract:Palmitoylation at cysteine residues is the only known reversible lipid modification and has been implicated in protein membrane association as well as function. There is growing evidence that many palmitoylated proteins have regulatory roles in dynamic cellular functions including membrane fusion. Recently, we identified Env7 as a palmitoylated vacuolar membrane protein‐kinase involved in negative regulation of vacuolar fusion. Our phylogenetic analyses have established Env7 as an ortholog of human STK16, an e… Show more
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