N¹-Heterocyclic Sulfanilamide Derivatives^*

Product Class 4: Benzimidazoles

“…For example, 1,1-dichloro-2-nitroethene reacts with 1,2-phenylenediamine at 10 8C in methanolic solution to form 2-(nitromethyl)-1H-benzimidazole (21, Y = NO 2 ) in 80% yield. [147] Previous methods of preparation of 2-(sulfonylamino)benzimidazoles 23 (Z = SO 2 R) have involved treatment of benzimidazol-2-amines with an appropriate sulfonyl chloride, [148] reaction of a 1,2-diaminoarene with sulfonylguanidines, [149] and synthesis from methyl sulfonyldithiocarbamates. [139] It is possible to make a wide variety of other 2-substituted benzimidazoles using the same general approach.…”

Derivatives of α-Amino Aldehydes III**School of Pharmacy, University of Wisconsin, Madison

“…Raiziss (8), however, tested a series of N-heterocyclic sulfanilamides including an us-triazine derivative which showed low activity against pneumococcal infections in comparison to sulfapyrazine. Raiziss (8), however, tested a series of N-heterocyclic sulfanilamides including an us-triazine derivative which showed low activity against pneumococcal infections in comparison to sulfapyrazine.…”

Characterization and biological evaluation of some novel pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidin-8-ones synthesized via the Gewald reaction

“…In the search of bioactive molecules and in continuation of previous work on the development of syntheses of polyfunctionally substituted heterocyclic com-pounds, a novel synthetic approach for the synthesis of 6-aryl-3-methyl-1,5,6,7--tetrahydro-8H-pyrazolo[3',4': 4,5]thieno [2,3-d]pyrimidin-8-ones (IIIa-j) is reported herein. All the newly synthesized compounds (IIIa-j) were evaluated for their antibacterial and antifungal activity.…”