N-succinyldesferrioxamine B: A potential radiopharmaceutical for assessing renal function

Herscheid, J. D. M.; Hoekstra, A.; Vos, Cornelis M.

doi:10.1007/bf00263255

Cited by 13 publications

(7 citation statements)

References 5 publications

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“…(1A). Generally, mAbs are conjugated with a bifunctional derivative of Df via an amide linkage for subsequent labeling with 89 Zr [15]. The hydroxamate groups within Df need to be temporarily blocked with Fe(III) before mAb conjugation.…”

Section: Radiolabeling Of 89zrmentioning

confidence: 99%

PET Tracers Based on Zirconium-89

Zhang¹,

Hong²,

Cai³

2011

CRP

143

131

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Positron emission tomography (PET) imaging with radiolabeled monoclonal antibodies has always been a dynamic area in molecular imaging. With decay half-life (3.3 d) well matched to the circulation half-lives of antibodies (usually on the order of days), 89Zr has been extensively studied over the last decade. This review article will give a brief overview on 89Zr isotope production, the radiochemistry generally used for 89Zr-labeling, and the PET tracers that have been developed using 89Zr. To date, 89Zr-based PET imaging has been investigated for a wide variety of cancer-related targets, which include human epidermal growth factor receptor 2, epidermal growth factor receptor, prostate-specific membrane antigen, splice variant v6 of CD44, vascular endothelial growth factor, carbonic anhydrase IX, insulin-like growth factor 1 receptor, among others. With well-developed radiochemistry, commercial availability of chelating agents for 89Zr labeling, increasingly widely available isotope supply, as well as successful proof-of-principle in pilot human studies, it is expected that PET imaging with 89Zr-based tracers will be a constantly evolving and highly vibrant field in the near future.

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Section: Radiolabeling Of 89zrmentioning

confidence: 99%

PET Tracers Based on Zirconium-89

Zhang¹,

Hong²,

Cai³

2011

CRP

143

131

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“…Both of these compounds target amine groups on lysine residues for conjugation to mAbs. Hersheid et al describe the procedure for modification to the carboxylate form [23], and the method for Df-Bz-NCS production is described by Perk et al [8]. Both forms are available commercially.…”

Section: Selective Chelation With Desferrioxamine B and Its Derivamentioning

confidence: 99%

89Zr Radiochemistry for Positron Emission Tomography

Severin¹,

Engle²,

Barnhart³

et al. 2011

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“…A hemi-succinate version of desferoxamine has been proposed for conjugation with antibodies. However, practical applications of this method have not been fully explored [177].…”

Section: Biornacrornoleculesmentioning

confidence: 99%