N-Substituted 1H-Pyrimidin-4-One Derivatives Possessing Anxiolytic Activity

Oganesyan, É. T.; Кодониди, И. П.; Бандура, А. Ф.; Sochnev, Vadim S.; Manvelyan, Eleonora; Sysa, V. Yu.

doi:10.1007/s11094-017-1615-2

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“…In 2017, Oganesyan and co-workers reported a synthesis of 1H-pyrimidin-4-one derivatives 405 by heating the mixture of N-acyl β-keto amide 403 and various amines 404 in HOAc/DMF. They also demonstrated the anxiolytic activity of these heterocyclic compounds (Scheme 101) [177]. In 2020, Ibraheem and co-workers reported an efficient synthesis of thieno [3,2-d]pyrimidine derivatives through an intramolecular condensation of β-keto amides derived from carbamyl-3-amino-thiophenes 406.…”

Section: Six-membered Heterocycles With Multiple Heteroatomsmentioning

confidence: 99%

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The applications of β‐keto amides for heterocycle synthesis

2022

Journal of Heterocyclic Chem

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β-Keto amides have multiple nucleophilic and electrophilic reaction sites within their molecular structures, which make them excellent building blocks for the construction of various heterocyclic compounds. In this Review, we summarized the applications of structurally diversified β-keto amides for the synthesis of (1) Five-membered heterocycles including furans, thiophenes, pyrroles, indoles, pyrazoles, triazoles, and their derivatives; (2) six-membered nitrogen-and oxygen-containing heterocycles such as pyridones, dihydropyridines, pyridines, quinolones, quinolines, pyranones and the like; (3) various lactams and some aza-aliphatic rings. The focus is on the multicomponent reactions which take advantage of the unique versatile reactivities of β-keto amides.

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Section: Six-membered Heterocycles With Multiple Heteroatomsmentioning

confidence: 99%

“…In 2017, Oganesyan and co‐workers reported a synthesis of 1 H ‐pyrimidin‐4‐one derivatives 405 by heating the mixture of N ‐acyl β ‐keto amide 403 and various amines 404 in HOAc/DMF. They also demonstrated the anxiolytic activity of these heterocyclic compounds (Scheme 101) [177].…”

Section: Six‐membered Heterocycles With Multiple Heteroatomsmentioning

confidence: 99%

The applications of β‐keto amides for heterocycle synthesis

2022

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

show abstract

N-Substituted 1H-Pyrimidin-4-One Derivatives Possessing Anxiolytic Activity

Cited by 1 publication

References 2 publications

The applications of β‐keto amides for heterocycle synthesis

The applications of β‐keto amides for heterocycle synthesis

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