N₂O₂‐chelate metal complexes with Schiff base ligand: Synthesis, characterisation and contribution as a promising antiviral agent against human cytomegalovirus

Abstract

A new Schiff base, (N,N \ -phenylene-(bis-1-ethyl-6-fluoro-7-(piperazine-1-yl)quinolone-3-carboxylic acid) and (Nor-o-phdn.2H 2 O), and its derived complexes with nickel (II), cobalt (II), copper (II), iron (III), yttrium (III), lanthanum (III), zirconium (IV) and uranium (VI) were synthesised and distinguished by different tools such as elemental analyses, magnetic properties, molar conductivity, spectroscopic methods (UV-Vis., IR and 1 H-NMR), mass spectrometry and thermogravimetric analysis. Depending on the spectroscopic data, Schiff base Nor-o-phdn.2H 2 O is coordinated to metal centres as a potentially tetradentate ligand via N 2 O 2 atoms. UV-Vis. and magnetic data suggest an octahedral-geometry for all mentioned complexes. Thermogravimetric

Synthesis and Spectroscopic Characterization of Schiff Base Metal Complexes, Biological Activity, and Molecular Docking Studies

“…The quantity and composition of atoms in a compound can be identified by examining its nuclear magnetic resonance (NMR) spectrum and calculating their proportions throughout the compound’s immediate environment. − The absorption peak in an NMR spectrum is determined by comparing the resonance frequency of a nucleus to a reference value. The NMR spectra of the ligand were acquired using CDCl 3 as the solvent, whereas those of the metal complexes were obtained using DMSO.…”

“…The powder X-ray diffraction (XRD) of samples exhibited distinct and well-defined crystalline peaks, which serve as evidence of their crystalline phase. − The distinction between the Schiff base design and the metal complexes becomes apparent due to the formation of distinct crystalline phases.…”

Synergistic effects of steric constraints and non-covalent interactions in copper(ii) chloro-nitro-benzoato complexes: synthesis, structural characterization, theoretical investigations, antimicrobial studies, and molecular docking analyses

“…Our sustained research curiosity in the structural and biological chemistry of copper( ii ) 8–19 led us to the selection of this metal ion besides aryl carboxylates as organic ligands (oxygen donors). Moreover, the importance of copper( ii ) complexes stems from the intrinsic property of the copper metal ion as a bioactive, redox-active, and relatively low-cost metal.…”

“…Moreover, the importance of copper( ii ) complexes stems from the intrinsic property of the copper metal ion as a bioactive, redox-active, and relatively low-cost metal. 18,20 Coordination complexes of copper( ii ) have applications in different emergent fields, such as crystal engineering, 1 catalysis, 21 sensing, 22 luminescence, 23 bio-organic and bio-inorganic chemistry. 24 On the other end, it is noteworthy that arylcarboxylates are considered edifice blocks in crystal engineering and self-assembly processes, owing to their (i) diverse coordination modes, (ii) ability to form strong intermolecular interactions, such as H-bonding, π⋯π or C–H⋯π interactions; and (iii) inherent biological activities (more potent and desirable drugs than their parent acids).…”

First Report on Several NO-Donor Sets and Bidentate Schiff Base and Its Metal Complexes: Characterization and Antimicrobial Investigation

“…In addition, Schiff bases are employed as ligands to create coordination compounds when coupled with metal ions [7,8]. Many biological applications of Schiff bases and their chelates are possible, due to their antibacterial, anticancer, antifungal, antimalarial, and antiviral properties [9][10][11].…”