N,S co-doped carbon dots as a stable bio-imaging probe for detection of intracellular temperature and tetracycline

Shi, Weilong; Guo, Feng; Han, Mumei; Yuan, Songhu; Guan, Wenxian; Li, Hao; Huang, Hui; Liu, Yang; Kang, Zhenhui

doi:10.1039/c7tb00810d

Cited by 127 publications

(52 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zhao and co‐workers12 pioneered the RTP of CDs by introducing a polymer poly(vinyl alcohol) as a protective matrix, and the CDs were used successfully for securing documents. Since then, RTP materials have been developed from CDs dispersed into polyurethane,13 silica gel,14 polymer composite matrix (urea and biuret),15 KAl(SO 4 ) 2 · x H 2 O,16 and NaCl hybrid crystals,17 which were mainly applied in the field of document security. Recently, Liu et al18 and Lin et al19 designed a matrix‐free RTP of NCDs.…”

Section: Introductionmentioning

confidence: 99%

Visible‐Light‐Excited Ultralong‐Lifetime Room Temperature Phosphorescence Based on Nitrogen‐Doped Carbon Dots for Double Anticounterfeiting

Gao

Zhang

Shuang

et al. 2020

Advanced Optical Materials

View full text Add to dashboard Cite

of RTP materials with excellent properties is always a challenge, and this can be attributed to the spin-forbidden nature of triplet exciton transitions. Till now, RTP materials mainly include metal complexes and pure organic compounds, [6] which have several disadvantages such as high cost, high toxicity, and complicated preparation process. Also, the commonly reported RTP materials can be excited only under ultraviolet light, and their excitation spectrum under the ultraviolet region is not convenient for certain applications. Contrary to ultraviolet light, visible light is safer to use and can penetrate deeper into biological analysis and imaging; hence easily used in practical applications. Besides, visible light is more superior than ultraviolet light and has received widespread applications. [7] Thus, enormous efforts have been devoted to discovering novel RTP materials that can be excited by visible light. Currently, only a few visible-light-induced phosphorescent materials [8] have been implemented.As one of the most popular nanomaterials, carbon dots (CDs) have attracted much interest because of their low toxicity, excellent optical performance, high light stability, and environmental friendliness. [9] They are widely applied in biological imaging, [10] securing documents, [11] and in light-emitting devices. [3] Moreover, CDs are effective optical URTP materials which makes them very attractive in anticounterfeiting. Zhao and co-workers [12] pioneered the RTP of CDs by introducing a polymer poly(vinyl alcohol) as a protective matrix, and the CDs were used successfully for securing documents. Since then, RTP materials have been developed from CDs dispersed into polyurethane, [13] silica gel, [14] polymer composite matrix (urea and biuret), [15] KAl(SO 4 ) 2 ·xH 2 O, [16] and NaCl hybrid crystals, [17] which were mainly applied in the field of document security. Recently, Liu et al. [18] and Lin et al. [19] designed a matrix-free RTP of NCDs. The synthesized CDs act as both a solidified host and a luminescent object in a solid-state without introducing an additional support matrix. Also, Dong et al. constructed a novel, matrix-free NCDs based on a one-step high-temperature polymerization method that binds a polyaspartic acid chain to the NCDs surface, and further designed it for safe inks. [20] These construction strategies overcame the complicated synthesis process of screening dispersion media and extended the utilization Visible light is ubiquitous and safer than ultraviolet light; however, synthesizing ultralong-lifetime room temperature phosphorescent (URTP) carbon dots (CDs) with visible-light excitation remains a formidable challenge. Herein, an easy and fast method for synthesizing visiblelight-excited URTP CDs is devised. The synthesized CDs have URTP lifetime of 1.51 s which is a relatively long life RTP lifetime ever reported. Furthermore, it is revealed that the dense core of CDs, the formation of long-chain polymers on the surface, and the presence of hydrogen bond skeleton play a crucial ...

show abstract

Section: Introductionmentioning

confidence: 99%

Visible‐Light‐Excited Ultralong‐Lifetime Room Temperature Phosphorescence Based on Nitrogen‐Doped Carbon Dots for Double Anticounterfeiting

Gao

Zhang

Shuang

et al. 2020

Advanced Optical Materials

View full text Add to dashboard Cite

show abstract

“…Analogously in a recent study, Zuo et al stated that owing to the pronounced temperature dependence of the fluorescence emission spectra, the resultant N and S co-doped CQDs can work as versatile nanothermometry devices by taking advantage of the temperature (5 to 80 • C) sensitivity of their emission intensity (F/F 0 )-as shown in Figure 20 [183]. In another investigation, Shi et al used the N and S co-doped CQDs as an effective temperature indicator that has exhibited good temperature-dependent fluorescence with a sensational linear response from 20 to 80 • C [184].…”

Section: Temperature Probementioning

confidence: 99%

Recent Advancements in Doped/Co-Doped Carbon Quantum Dots for Multi-Potential Applications

Kandasamy

2019

View full text Add to dashboard Cite

Carbon quantum dots (CQDs)/carbon nanodots are a new class of fluorescent carbon nanomaterials having an approximate size in the range of 2–10 nm. The majority of the reported review articles have discussed about the development of the CQDs (via simple and cost-effective synthesis methods) for use in bio-imaging and chemical-/biological-sensing applications. However, there is a severe lack of consolidated studies on the recently developed CQDs (especially doped/co-doped) that are utilized in different areas of application. Hence, in this review, we have extensively discussed about the recent development in doped and co-doped CQDs (using elements/heteroatoms—e.g., boron (B), fluorine (F), nitrogen (N), sulphur (S), and phosphorous (P)), along with their synthesis method, reaction conditions, and/or quantum yield (QY), and their emerging multi-potential applications including electrical/electronics (such as light emitting diode (LED) and solar cells), fluorescent ink for anti-counterfeiting, optical sensors (for detection of metal ions, drugs, and pesticides/fungicides), gene delivery, and temperature probing.

show abstract

“…The importance of pursuing further work on carbon dots could be gauged from their application potential in versatile fields. Their photoluminescence properties provide wide appeal in applications in theranostics especially as intracellular probes ,. A case in point is intra cellular pH, which plays pivotal roles in cellular apoptosis, cell cycle, ion transportation, and endocytosis ,.…”

Section: Introductionmentioning

confidence: 99%

“…Their photoluminescence properties provide wide appeal in applications in theranostics especially as intracellular probes. [18,19] A case in point is intra cellular pH, which plays pivotal roles in cellular apoptosis, cell cycle, ion transportation, and endocytosis. [20,21] Abnormal pH values in organelles, usually coupled with various cellular dysfunctions, results diseases like cancer, Alzheimer's and myocardial ischemia.…”

Section: Introductionmentioning

confidence: 99%

Boron Doped Carbon Dots with Unusually High Photoluminescence Quantum Yield for Ratiometric Intracellular pH Sensing

et al. 2019

View full text Add to dashboard Cite

Herein we report that boron doping in carbon dots results in increased photoluminescence (PL) quantum yield, which could be used for ratiometric intracellular pH sensing in cancer cell lines. Using a mixture of citric acid monohydrate, thiourea, and boric acid, microwave‐assisted synthesis of boron doped blue emitting carbon dots (B‐Cdots) with an average size of 3.5±1.0 nm was achieved. For B‐Cdots, the maximum quantum yield (QY) was observed to be 25.8 % (11.1 % (w/w) H3BO3 input concentration), whereas, the same was calculated to be 16.9 % and 11.4 % for Cdots (synthesized from citric acid monohydrate and thiourea only) and P‐Cdots (phosphorus doped carbon dots; synthesized using citric acid monohydrate, thiourea and phosphoric acid) (11.1 % (w/w) H3PO4 input concentration), respectively. The observed luminescence efficiencies as obtained from steady state and time‐resolved photoluminescence measurements suggest an alternative emission mechanism due to boron/phosphorus doping in carbon dots. We furthermore demonstrated facile composite formation using B‐Cdots and another carbon dots with orange emission in presence of polyvinyl alcohol (PVA), resulting in white light emission (0.31, 0.32; λex 380 nm). The white light emitting composite enabled ratiometric pH sensing in the aqueous medium and showed favorable uptake properties by cancerous cells for intracellular pH sensing as well.

show abstract

N,S co-doped carbon dots as a stable bio-imaging probe for detection of intracellular temperature and tetracycline

Abstract: N,S-CDs display an unambiguous bioimaging ability in the detection of intracellular temperature and tetracycline with satisfactory results.

Cited by 127 publications

References 47 publications

Visible‐Light‐Excited Ultralong‐Lifetime Room Temperature Phosphorescence Based on Nitrogen‐Doped Carbon Dots for Double Anticounterfeiting

Visible‐Light‐Excited Ultralong‐Lifetime Room Temperature Phosphorescence Based on Nitrogen‐Doped Carbon Dots for Double Anticounterfeiting

Recent Advancements in Doped/Co-Doped Carbon Quantum Dots for Multi-Potential Applications

Boron Doped Carbon Dots with Unusually High Photoluminescence Quantum Yield for Ratiometric Intracellular pH Sensing

Contact Info

Product

Resources

About