N-Pep-12 supplementation after ischemic stroke positively impacts frequency domain QEEG

Popa, Livia; Iancu, Mihaela; Livint, Gheorghe; Balea, Maria; Dina, Constantin; Văcăraș, Vitalie; Vlădescu, Cristian; Bălănescu, Laura; Strilciuc, Ștefan; Mureșanu, Dafin F.

doi:10.1007/s10072-021-05406-9

Neurol Sci

2021

DOI: 10.1007/s10072-021-05406-9

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N-Pep-12 supplementation after ischemic stroke positively impacts frequency domain QEEG

Livia Popa

Mihaela Iancu

Gheorghe Livint

et al.

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2024

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Cited by 5 publications

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“…8,9 Other studies have explored a possible negative association between DTABR, DAR, and cognition in a 90-day period after stroke. 10 These results imply resting-state EEG metrics contain unique information about motor impairment. 11 Magnetic resonance imaging and computed tomography scans are useful for identifying structural characteristics of the lesion such as location and size, which are clinically important for diagnosing stroke and identifying interventions for acute stroke but do not offer insight into the underlying mechanisms of recovery.…”

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confidence: 90%

“…The existing literature indicates that elevated DTABR and DAR in acute stroke patients are useful measures of the degree of poststroke motor impairment 8,9 . Other studies have explored a possible negative association between DTABR, DAR, and cognition in a 90-day period after stroke 10 . These results imply resting-state EEG metrics contain unique information about motor impairment 11 .…”

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confidence: 98%

See 1 more Smart Citation

Alteration in Resting-State Brain Activity in Stroke Survivors After Repetitive Finger Stimulation

He,

Sikora,

James

et al. 2024

Am J Phys Med Rehabil

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Objective This quasi-experimental study examined the effect of repetitive finger stimulation on brain activation in eight stroke and seven control subjects, measured by quantitative electroencephalogram (qEEG). Methods We applied five minutes of two Hz repetitive bilateral index finger transcutaneous electrical nerve stimulation (TENS), and compared differences pre and post TENS using qEEG metrics delta/alpha ratio (DAR) and delta-theta/alpha-beta ratio (DTABR). Results Between group differences pre and post-stimulation were significantly different in the DAR (z = -2.88 with p = 0.0040) and the DTABR variables (z = -3.90 with p < .0001). Significant decrease in the DAR and DTABR variables after the TENS was detected only in the stroke group (DAR diff = 3.87 p = .0211), (DTABR diff = 1.19, p = .0074). Conclusions The decrease in qEEG metrics in the stroke group may indicate improved brain activity following TENS. This finding may pave the way for a future novel therapy based on TENS and qEEG measures to improve brain recovery after stroke.

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confidence: 90%

mentioning

confidence: 98%

Alteration in Resting-State Brain Activity in Stroke Survivors After Repetitive Finger Stimulation

He,

Sikora,

James

et al. 2024

Am J Phys Med Rehabil

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Advancing clinical neuroscience in Romania: a decade of experience from the RoNeuro Institute for Neurological Research and Diagnostic

Mureşanu

2024

JMedLife

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Memory-Guided Saccades in Subacute and Chronic Stroke: Secondary Data Analysis of the N-PEP-12 Clinical Study

Ștefănescu,

Balea,

Chelaru

et al. 2024

Biomedicines

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Background: Ischemic stroke (IS) often leads to cognitive and motor impairments. This study aimed to investigate whether Memory-Guided Saccade Tasks (MGSTs) could be used to assess cognitive function in stroke patients. Methods: A secondary data analysis was conducted on 62 individuals with supratentorial IS. Eye-tracking metrics from MGST were correlated with established neuropsychological assessments, including the Montreal Cognitive Assessment (MoCA) and Hospital Anxiety and Depression Scale (HADS). Results: Age correlated negatively with memory-guided saccade (MGS) accuracy (ρ = −0.274) and positively with late errors (ρ = 0.327). Higher Montreal Cognitive Assessment (MoCA) scores were associated with faster corrective saccades (ρ = 0.259). Increased anxiety (HADS-A) and depression (HADS-D) levels correlated with higher early error rates (ρ = 0.325 and ρ = 0.311, respectively). The Color Trails Test and Digit Span test performance also correlated with various MGS parameters. Conclusions: While some correlations were found between cognitive measures and eye-tracking metrics, further research is needed to validate MGST as a tool for cognitive assessment in a more homogenous stroke population.

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N-Pep-12 supplementation after ischemic stroke positively impacts frequency domain QEEG

Cited by 5 publications

References 47 publications

Alteration in Resting-State Brain Activity in Stroke Survivors After Repetitive Finger Stimulation

Alteration in Resting-State Brain Activity in Stroke Survivors After Repetitive Finger Stimulation

Advancing clinical neuroscience in Romania: a decade of experience from the RoNeuro Institute for Neurological Research and Diagnostic

Memory-Guided Saccades in Subacute and Chronic Stroke: Secondary Data Analysis of the N-PEP-12 Clinical Study

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