N-ortho-Ferrocenyl benzoyl dipeptide esters: Synthesis, structural characterization and in vitro anti-cancer activity of N-{ortho-(ferrocenyl)benzoyl}-glycine-l-alanine ethyl ester and N-{ortho-(ferrocenyl)benzoyl}-l-alanine-glycine ethyl ester

Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety

“…In the light of these facts, investigation in the field of ferrocene chemistry has seen a drastic increase in attention over the past years, particularly in area peptide mimetic models. Conjugations of ferrocene scaffolds with biomolecules such as DNA, carbohydrates, amino acids and peptides are recognized to provide novel compounds by combining the beneficial properties of each component [2][3][4][5][6][7][8][9][10][11]. These bioconjugates of ferrocene with amino acids or peptides are of great interest as structural mimetics of natural peptides for protein folding and construction of highly-ordered assemblies.…”

Ruthenium(II) carbonyl complexes of dehydroacetic acid thiosemicarbazone: Synthesis, structure, light emission and biological activity

“…The interaction of small molecules such as ''CO" and ''O 2 " with transition metal complexes particularly those containing a ruthenium metal centre coordinated to nitrogen and oxygen donor ligands have attracted a great deal in recent years. Kenny et al have recently reported the in vitro anticancer activity of some N-ortho-ferrocenyl benzoyl dipeptide esters [17]. Organometallic technetium and rhenium complexes of a 5 0 -carboxamide 5-ethyl-2 0 -deoxyuridine derivative are able to selectively inhibit Herpes simplex virus thymidine kinase type 1 (HSV1-TK) [18].…”

Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1

“…The dipeptidyl derivatives were synthesized using the standard DCC/HOBt protocol (Scheme 1) [13][14][15] . Chiral integrity can be preserved by the use of 1-hydroxybenzotriazole (HOBt).…”