N,O-bidentate ligands-based salicylic spiroborates: A bright frontier of bioimaging

Lugovik, Kseniya I.; Fomin, Timur A.; Минин, Артем С.; Поздина, Варвара А.; Шевырин, Вадим А.; Benassi, Enrico; Belskaya, Nataliya P.

doi:10.1016/j.dyepig.2022.110165

Cited by 7 publications

(2 citation statements)

References 52 publications

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“…5,7,29 In 2022, Belskaya's group reported a series of N,O-bidentate ligand-based salicylic spiroborates, and demonstrated that nitrogen atoms participate in the electronic distribution and transfer during the photo-physical process. 30 Thus, it is very possible to develop a drug molecule suitable for integrated diagnosis and treatment theoretically.…”

Section: Drug Molecular Screening and Geometry Optimizationmentioning

confidence: 99%

A study on optical properties of various hot drug molecules by 2020

et al. 2023

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Section: Drug Molecular Screening and Geometry Optimizationmentioning

confidence: 99%

A study on optical properties of various hot drug molecules by 2020

et al. 2023

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“…There is also a considerable amount of attention paid to the boron-containing payloads in boron neutron capture therapy ( 30 ) and antibody-drug conjugates ( 31 , 32 ). Furthermore, π-conjugated boracycles, such as BODIPY, can act as the fluorescent probes in vivo ( 33 , 34 ). In the field of bio-click chemistry, the boronic acid units have been recognized to facilitate the imine formation including iminoboronates ( 28 ) and diazaborines ( 35 ).…”

Section: Introductionmentioning

confidence: 99%

Alkynone β-trifluoroborates: A new class of amine-specific biocompatible click reagents

Teng

Zhang

et al. 2023

Sci. Adv.

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Amine-targeting reactions that work under biocompatible conditions or in water are green processes that are extremely useful for the synthesis of functional materials and biotherapeutics. Unfortunately, despite the usefulness of this reaction, there are very few good amine-specific click methods reported thus far. Here, we report an amine-specific click reagent using alkynone β-trifluoroborates as the electrophiles. These boron-containing alkynyl reagents exhibit extremely high chemoselectivity toward amines even in the presence of thiols. The resulting oxaboracycle products are bench-stable, displaying the reactivities of both organoborates and enaminones. Intrinsic advantages of this methodology include benign reaction conditions, operational simplicity, remarkable product stability, and excellent chemoselectivity, which satisfy the criteria of click chemistry and demonstrate the high potential in bioconjugation. Hence, this water-based chemical approach is also applicable to the modification of native amino acids, peptides, and proteins. Ultimately, the essential role of water during the reaction was elucidated.

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