N,N-Dimethylglycine in patients with progressive multiple sclerosis: result of a pilot double-blind, placebo, controlled randomized clinical trial

Wolfsegger, Thomas; Böck, K; Schimetta, Wolfgang; Oertzen, Tim J. von; Assar, Hamid

doi:10.1186/s42466-021-00126-z

Cited by 4 publications

(2 citation statements)

References 6 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can be used as an antioxidant in the food industry and as a pharmaceutical intermediate to synthesize various biochemical drugs in the pharmaceutical industry [ 31 ]. Nowadays, DMG has been widely used as a dietary supplement [ 32 ], an amino acid-based surfactant [ 33 ], and a source of glycine for glutathione synthesis to improve the antioxidant capacity in the body [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

Dimethylglycine Can Enhance the Cryopreservation of Red Blood Cells by Reducing Ice Formation and Oxidative Damage

Liu

Ekpo

et al. 2023

IJMS

View full text Add to dashboard Cite

The cryopreservation of red blood cells (RBCs) holds great potential for ensuring timely blood transfusions and maintaining an adequate RBC inventory. The conventional cryoprotectants (CPAs) have a lot of limitations, and there is an obvious need for novel, efficient, and biocompatible CPAs. Here, it is shown for the first time that the addition of dimethylglycine (DMG) improved the thawed RBC recovery from 11.55 ± 1.40% to 72.15 ± 1.22%. We found that DMG could reduce the mechanical damage by inhibiting ice formation and recrystallization during cryopreservation. DMG can also scavenge reactive oxygen species (ROS) and maintain endogenous antioxidant enzyme activities to decrease oxidative damage during cryopreservation. Furthermore, the properties of thawed RBCs were found to be similar to the fresh RBCs in the control. Finally, the technique for order performance by similarity to ideal solution (TOPSIS) was used to compare the performance of glycerol (Gly), hydroxyethyl starch (HES), and DMG in cryopreservation, and DMG exhibited the best efficiency. This work confirms the use of DMG as a novel CPA for cryopreservation of RBCs and may promote clinical transfusion therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Dimethylglycine Can Enhance the Cryopreservation of Red Blood Cells by Reducing Ice Formation and Oxidative Damage

Liu

Ekpo

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…It has been used in broiler feed as a food additive, as it has been shown to be able to enhance the productive performance of broiler chickens, represented by average Body weight, weekly weight gain, feed consumption and feed conversion rate. It also has an important role in protecting the liver, stomach, and intestines from oxidative damage being an effective antioxidant [5,8,9]. DMG supplementation is considered to improve protein digestibility and the nitrogen-free extract has the ability to digest dry and organic materials [5].…”

Section: Introductionmentioning

confidence: 99%

Response of Broiler to Addition Dimethylglycine of Normal and Low-Energy Diets in Productive Performance

Hazaa,

Nafea

2023

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

The research was conducted in poultry fields in the Department of Animal Production / College of Agriculture / University of Anbar for the period starting from the third of September 2022 until the fourteenth of December 2022 (42 days), and The purpose of the study was to find out the effect adding dimethylglycine to diets Regular and low-energy diets on productive performance of broiler chickens. 180 Ross 308 unsexed chicks, 1 day old and average weight of 37.8 g, were used, distributed to two groups depending on the energy level in the diet (normal diet and low energy diet), each group was treated with dimethylglycine at levels (0, 300 and 600 mg / In kg of fed), The results showed a significant improvement (P < 0.05) for the addition treatments 0, 300 and 600 mg / kg feed in average body weight, weight gain and feed conversion factor compared to control treatments. As for the interaction between the trait of the diet and the additives, a significant improvement (P < 0.05) was observed in the treatment of the regular ration by adding 300 DMG / kg feed compared to the rest of the treatments, then this was followed by the treatment with reduced food rations without addition or with the addition of 300 DMG / kg fed. We conclude that adding DMG at the above levels to the regular and low-energy diets The productive performance of broilers improved without any negative effect.

show abstract

Recovery of N, N-dimethylglycine (DMG) from dimethylglycine hydrochloride by bipolar membrane electrodialysis

Zheng

Jin

Zhang

et al. 2022

Chemical Engineering and Processing - Process Intensification

View full text Add to dashboard Cite

N,N-Dimethylglycine in patients with progressive multiple sclerosis: result of a pilot double-blind, placebo, controlled randomized clinical trial

Cited by 4 publications

References 6 publications

Dimethylglycine Can Enhance the Cryopreservation of Red Blood Cells by Reducing Ice Formation and Oxidative Damage

Dimethylglycine Can Enhance the Cryopreservation of Red Blood Cells by Reducing Ice Formation and Oxidative Damage

Response of Broiler to Addition Dimethylglycine of Normal and Low-Energy Diets in Productive Performance

Recovery of N, N-dimethylglycine (DMG) from dimethylglycine hydrochloride by bipolar membrane electrodialysis

Contact Info

Product

Resources

About