N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma

Cyclin D1 Is Transcriptionally Down-Regulated by ZO-2 via an E Box and the Transcription Factor c-Myc

“…Besides cyclin D1 (Philipp et al, 1994), other genes repressed in c-Myc-transformed cells included those that encode cell adhesion proteins, such as the ␤1 integrin subunit (Judware and Culp, 1995); molecules of the immune system, such as major histocompatibility complex class I and lymphocyte function-associated antigen-1 (Bernards et al, 1986;Versteeg et al, 1988;Inghirami et al, 1990); and cell cycle regulators, such as C/EBP␣ (Freytag and Geddes, 1992) and c-Myc itself (Penn et al, 1990). These findings suggested that gene repression contributes significantly to the phenotype of c-Myc transformed cells.…”

Defective MHC class I antigen surface expression promotes cellular survival through elevated ER stress and modulation of p53 function

“…It is to be noted that oncogene-mediated cellular transformation and subsequent tumorigenesis -in which conditions of hypoxia and nutrient deprivation prevail -are also associated with reduction in class I expression. [25][26][27] Conversely, treatment with genotoxic agents leading to cell cycle arrest was associated with increased class I expression. Supporting evidence comes from pathological conditions in which cells undergoing arrest or cell death have also been associated with increased MHC class I expression.…”

A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts

“…Many genes have been implicated as cMyc targets, including genes involved in cell cycle regulation: cdc25A, cyclin E, cyclin D2 (Bouchard et al, 1999;Galaktionov et al, 1996;Perez-Roger et al, 1997); apoptosis: p53 (Reisman et al, 1993); DNA biosynthesis: cad, ODC (Bello et al, 1993;Miltenberger et al, 1995); macromolecular synthesis: eIF-4E and MrDb (Grandori et al, 1996;Rosenwald, 1996); and genes with unknown function: rcl and a-prothymosin (Eilers et al, 1991;Lewis et al, 1997). Myc proteins have also been implicated in the repression of several genes including MHC class I antigens, c-myc, gadd45 and C/EBP (Bernards et al, 1986;Li et al, 1994;Marhin et al, 1997;Penn et al, 1990). For many genes it is still unclear whether they are direct or indirect targets and none of them appears to explain the diverse biological activities of c-Myc.…”