N-Methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): A novel bile acid profile in Perciform fish

Satoh, Rika; Saito, Tetsuya; Ogata, Hiroaki; Ohsaki, Ayumi; Iida, Takashi; Asahina, Kiyoshi; Mitamura, Kuniko; Ikegawa, Shigeo; Hofmann, Alan F.; Hagey, Lee R.

doi:10.1016/j.steroids.2013.11.014

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…SL and other sulfated metabolites observed in the PIS97 mass spectra were identified through the online databases available including the Human Metabolome Database (HMDB, www.hmdb.com), LipidMaps (www.lipidmaps.com), the Food Component Database (FooDB, www.foodb.ca) and the PhytoHub (www.phytohub.eu). Confirmation of metabolite hits retrieved from database search were confirmed using fragmentation pattern acquired during enhanced product ion (EPI) experiments and cross-referenced with fragmentation patterns (MS/MS data) published in the literature (Hofmann et al, 2016;Kongmanas et al, 2010;Sasso et al, 2016;Satoh Née Okihara et al, 2014).…”

Section: Sl and Metabolite Identification Workflowmentioning

confidence: 88%

“…The mass range selected between m/z 350-1000 excludes the detection of low MW metabolites (<350 Da) which could lead to peak saturation and ion suppression effects. achieved through fragmentation patterns in EPI mass spectra cross-referenced with available literature (Kongmanas et al, 2010;Sasso et al, 2016;Satoh Née Okihara et al, 2014). In general, SL exhibit abundant product ion at m/z 97.0 (base peak) (Mirzaian et al, 2015b) in the negative ion mode.…”

Section: Optimization Of Sl Analysis and Detection Conditionsmentioning

confidence: 99%

“…Other ions observed with low R. A. at m/z 418.4, 446.4, 474.4, and 490.4 in the PIS 97 mass spectra of plasma and neutrophils extracts were attributed to N-acyl taurine lipids ( Supplemental Table S1) based on the signature fragments of sulfonate-based compounds at m/z 124, 107 and 80 (Sasso et al, 2016;Satoh Née Okihara et al, 2014) and a distinct ratio of signature fragments (Supplemental Figure S3). Bearing in mind the SL signature fragments, several other ions were identified as sulfate-based lipids though its structure was not entirely deciphered.…”

Section: Optimization Of Sl Analysis and Detection Conditionsmentioning

confidence: 99%

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Sulfate-based lipids: Analysis of healthy human fluids and cell extracts

Dias

Ferreira

Грубер

et al. 2019

Chemistry and Physics of Lipids

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Section: Sl and Metabolite Identification Workflowmentioning

confidence: 88%

Section: Optimization Of Sl Analysis and Detection Conditionsmentioning

confidence: 99%

Section: Optimization Of Sl Analysis and Detection Conditionsmentioning

confidence: 99%

See 1 more Smart Citation

Sulfate-based lipids: Analysis of healthy human fluids and cell extracts

Dias

Ferreira

Грубер

et al. 2019

Chemistry and Physics of Lipids

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“…It also occurs to a variable extent in mammals ( 82 ). In some angelfi sh species, N -methyltaurine conjugates are present ( 149 ), the Nmethyltaurine thought to be of dietary origin. Similarly, in some marine fi sh, bile acids are conjugated with cysteinolic acid, a hydroxy-ethyl derivative of taurine that is of dietary origin ( 150 ).…”

Section: Conjugationmentioning

confidence: 99%

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Hofmann

Hagey

2014

Journal of Lipid Research

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297

284

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conceptions are rare, and provocative judgments stand the test of time. Let us also hope that this effort will be both useful and entertaining. Each of the topics discussed merits at least a full length article, so there will be, of necessity in many instances, consideration of only what we perceive to be the highlights. THE EBB AND FLOW OF MEDICAL INTEREST IN BILE ACIDSAfter the elucidation of the true chemical structure of bile acids in 1932 (see below), there was little interest in bile acids in the Western world. One exception to this statement was the laboratory of Siegfried Thannhauser, who wrote the fi rst textbook of metabolic biochemistry in Germany. He studied cholesterol and bile acid balance in the biliary fi stula dog ( 1 ). During this time, bile acids were sold as liver tonics and laxatives, but there were no placebo-controlled studies showing effi cacy. Indeed, bile acids were considered by the medical profession to have no useful therapeutic properties. The tri-oxo derivative of cholic acid (called "dehydrocholic acid") was known to induce bile fl ow in animals ( 2 ), and was occasionally used to stimulate bile fl ow in patients; but again there were no controlled studies showing effi cacy in hepatobiliary disease.

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“…[19]. At present, in mammals, profile of BAs has got a lot of results and interesting discoveries have been found [20,21], while there were few reports about concentrated on BAs in fish, since most of them focused on roles of BAs in fish pheromone systems and identification of some new BAs in saltwater fish [22][23][24][25]. In general, BAs in fish have less study, and which is relatively one-sided [26][27][28].Previous studies of our team suggested that high plant protein induced common carp liver injury, while BAs supplementary could help to alleviate [29], but which BA played the leading role or how to affect liver health?…”

Section: Introductionmentioning

confidence: 99%

Effects of Bile Acids Supplement in High Plant Protein Diet on Common Carp (Cyprinus Carpio) Bile Acids Profile and Hepatopancreas Health

Wang¹,

Yao²,

Fall³

et al. 2021

Preprint

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BackgroundBile acids (BAs) have considerable importance in the metabolism of glycolipid and cholesterol. BAs profile in mammals has been widely reported, but lacking in fishes. The purpose of the present study is to clarify BAs profiles of common carp and how exogenous additions of BAs could alleviate hepatopancreas injured of common carp under a high plant protein diet. A 11-week feeding trial was conducted with high plant protein diet (18%) (HP) and high plant protein diet (18%) added 600 mg/kg BAs (HP+BAs) for Common carp, and then the UHPLC-MS/MS technology was used to analyze the BAs in the bile and plasma of two groups. ResultsHP could induce vacuolation of hepatocytes and accumulation of glycogen in Common carp, while these phenotypes were significantly improved in HP+BAs group. In addition, BAs profile of HP group and HP+BAs group were described in detail, for Common carp bile with treatment by exogenous BAs, TCA, CA, T β MCA and T ω MCA were the main components. Furthermore, in HP+BAs group plasma, CDCA, CA, LCA, and GCDCA increased significantly, they could activate TGR5, the activation of hepatopancreas TGR5 might regulate glucose metabolism to relieve hepatopancreas glycogen accumulation. ConclusionsHP could induce glycogen accumulation in common carp hepatopancreas while supplemented BAs to HP could mitigate this symptom. And we determined that the reduction of common carp hepatopancreas glycogen accumulation in the HP+BAs group is importantly related to the change in the endogenous BAs profile after the addition of BAs in HP through an integrated bile acids profile determination by UHPLC-MS/MS . This study has important guiding significance for aquaculture.

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N-Methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): A novel bile acid profile in Perciform fish

Cited by 8 publications

References 20 publications

Sulfate-based lipids: Analysis of healthy human fluids and cell extracts

Sulfate-based lipids: Analysis of healthy human fluids and cell extracts

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Effects of Bile Acids Supplement in High Plant Protein Diet on Common Carp (Cyprinus Carpio) Bile Acids Profile and Hepatopancreas Health

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