N-methyl dihydronicotinamide

Hutton, Robert F.; Westheimer, F. H.

doi:10.1016/s0040-4020(01)82613-2

Cited by 52 publications

(19 citation statements)

References 12 publications

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“…The addition is also believed to proceed at both the a-and g-carbon centres under kinetic control and only at the g-carbon under thermodynamic control. 27 The Kröhnke procedure [28][29][30] and sodium dithionite reduction [31][32][33] are examples of reactions involving addition of nucleophiles at g-position. The Kröhnke procedure, [28][29][30] consisting of base-catalysed reaction of ketones with alkyl or N-acyl pyridinium salts, was investigated years ago (Scheme 30).…”

Section: Synthesis Of 14-dihydropyridinesmentioning

confidence: 99%

Synthesis, utility and medicinal importance of 1,2- & 1,4-dihydropyridines

2017

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Dihydropyridine (DHP) is among the most beneficial scaffolds that have revolutionised pharmaceutical research with unprecedented biological properties. Over the years, metamorphosis of easily accessible 1,2-and 1,4-dihydropyridine (1,4-DHP) intermediates by synthetic chemists has generated several drug molecules and natural products such as alkaloids. The 1,4-dihydropyridine (1,4-DHP) moiety itself is the main fulcrum of several approved drugs. The present review aims to collate the literature of 1,2-and the 1,4-DHPs relevant to synthetic and medicinal chemists. We will describe various methodologies that have been used for the synthesis of this class of compounds, including the strategies which can furnish enantiopure DHPs, either by asymmetric synthesis or by chiral resolution.We will also elaborate the significance of DHPs towards the synthesis of natural products of medicinal merit.

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Section: Synthesis Of 14-dihydropyridinesmentioning

confidence: 99%

Synthesis, utility and medicinal importance of 1,2- & 1,4-dihydropyridines

2017

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“…This was analyzed for deuterium and found to contain about one atom per molecule. (88,138) in the pyridine ring of the coenzyme. Although the pathway for the oxidation is therefore clear, the intimate details of mechanism are still obscure.…”

Section: Enzymes Plus Coenzymesmentioning

confidence: 99%

Mechanisms Related to Enzyme Catalysis

Westheimer¹

1962

Advances in Enzymology - And Related Areas of Molecular Biology

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“…After Hantzsch, multifarious new methods have been nurtured for the synthesis of original molecule. 1,4-DHP's attracted more attention, thanks to its presence in the coenzyme, diphospho pyridine nucleotide (DPNH) [2] and identification as bio-active material. In the present scenario many representatives have been commercialised such as nifedipine [3], felodipine [4], nicardipine [5], amlodipine [6] and even more have made their presence felt in the market [7] in the treatment of angina and hypertension.…”

Section: Introductionmentioning

confidence: 99%