N-methyl-d-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats

Érces, Dániel; Varga, Gabriella; Fazekas, Borbála; Kovács, Tamás; Tőkés, Tímea; Tiszlavicz, László; Fülöp, Ferenc; Vécsei, László; Boros, Mihály; Kaszaki, József

doi:10.1016/j.ejphar.2012.06.044

Cited by 37 publications

(33 citation statements)

References 42 publications

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“…Interestingly, treatment with KYNA, which is N -methyl- d -aspartate receptor antagonist decreased obstruction-caused intestinal hypermotility in dogs and 2,4,6-trinitrobenzensulfonic acid-induced colitis in rats [14, 36]. Moreover, some experimental studies documented, that treatment with KYNA significantly reduced the level of inflammatory mediators, such as TNFα and interleukine 6 [36, 37]. On the other hand, circulating cytokines promote kynurenine metabolism and subsequent generation of tryptophan metabolites, including KYNA [2, 3, 5, 38].…”

Section: Discussionmentioning

confidence: 99%

Changes in Plasma Kynurenic Acid Concentration in Septic Shock Patients Undergoing Continuous Veno-Venous Haemofiltration

et al. 2013

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Kynurenic acid (KYNA) is one of the end products of tryptophan metabolism. The aim of this study was to analyse plasma KYNA concentration in septic shock patients (SSP) with acute kidney injury (AKI) undergoing continuous veno-venous haemofiltration (CVVH). Changes in KYNA content were compared to alterations in the levels of procalcitonin (PCT), C-reactive protein and lactate. Adult SSP with AKI were examined. Measurements were conducted at seven time points: before beginning CVVH and at 6, 12, 24, 48, 72 and 96 h after the beginning of CVVH. Based on clinical outcomes, the data were analysed separately for survivors and non-survivors. Twenty-seven patients were studied. CVVH was associated with reduced plasma KYNA concentration only in survivors. Plasma KYNA concentration correlated with the levels of lactate and PCT only in survivors. (1) CVVH reduced plasma KYNA concentration only in survivors; (2) lack of this reduction may predict fatal outcomes in SSP.

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Section: Discussionmentioning

confidence: 99%

Changes in Plasma Kynurenic Acid Concentration in Septic Shock Patients Undergoing Continuous Veno-Venous Haemofiltration

et al. 2013

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“…Kynureine is the immediate precursor for kynurenic acid synthesis by the enzyme IDO and kynurenic acid can act as antagonist of NMDA glutamate receptors and as an antagonist at nicotinic acetylcholine receptors . Kynurenic acid inhibits inflammation in the 2,4,6‐trinitrobenzenesulfonic acid (TNBS) model of colitis in rats by blocking enteric NMDA receptors . Gut derived kynurenic acid may also have effects on the central nervous system by affecting mood and cognition …”

Section: Host Genetics Obesity Microbiome and Gut Healthmentioning

confidence: 99%

Beneficial actions of microbiota‐derived tryptophan metabolites

Galligan

2018

Neurogastroenterology Motil

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Tryptophan is an important dietary amino acid and it is the precursor for 5-hydroxytryptamine synthesis in the nervous system and by enterochromaffin cells in the gut mucosa. Tryptophan is also metabolized by enzymes in the gut mucosa and also by enzymes produced by the gut microbiome. Diet and the microbiome can contribute to metabolic disease in part by causing intestinal inflammation and increased permeability. In this issue of Neurogastroenterology and Motility, Jennis et al. test the hypothesis that indole tryptophan metabolites produced by gut bacteria might be responsible for the anti-inflammatory and beneficial metabolic effects of the gut microbiome and Roux-en-Y gastric bypass surgery for weight loss by obese patients. The authors identified indole-3-propionic acid as the beneficial metabolite. A review of the literature also revealed the beneficial effects of tryptophan metabolites on diabetes and metabolic disease and on inflammatory bowel disease. Taken together, these data highlight another health benefit of the intestinal microbiome, which produces beneficial products from dietary amino acids especially tryptophan.

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“…Erces et al [41] An NMDA receptor antagonist reduced inflammatory dysmotility of the colon, possibly, indirectly, by reducing inflammation Sogawa et al [42] CNP stimulates NPR-B mediated cGMP production; thereby, contributing to GI motility Studies in the past two decades have suggested, in particular, a possible relationship between diarrheaprominent IBS (D-IBS) and mast cells [53]. This relationship is complex and it seems unlikely at present that changes in mast cells can serve as reliable biomarkers for IBS or predict responses to therapy [54].…”

Section: Other Factors That May Influence Colonic Sensorineural Functionmentioning

confidence: 99%

“…A summary of recent findings is provided in Table 2 [ [34][35][36][37][38][39][40][41][42][43]44 & ]. A summary of recent findings is provided in Table 2 [ [34][35][36][37][38][39][40][41][42][43]44 & ].…”

Section: Neurotransmission and Neuromodulationmentioning

confidence: 99%