“…The N-methyl-D-aspartate receptor (NMDAR) is one of the main excitatory receptors in the central nervous system, with essential roles in regulating neuroplasticity, excitatory neurotransmission, and the development of learning and memory (Chen et al, 2021). Genes encoding NMDAR subunits (such as GRIN1, GRIN2A, and GRIN2B) have been identified to be associated with broad-spectrum phenotypes, including epilepsies, epilepsies with NDD, and NDD without seizures (Endele et al, 2010;Charron et al, 2022). Similar to NMDAR genes, an increasing number of genes encoding NMDAR-associated proteins have been identified to be associated with a broad phenotypic spectrum, such as DLG4 and SYNGAP1 (Moutton et al, 2018;Agarwal et al, 2019).…”