[N-methyl-3H]methylphenazepam, a new ligand for diazepin receptors

Effect of perfluorodecalin on picrotoxin toxicity and some detoxication systems

“…This is in accordance with data reported previously on an increased anticonvulsive efficacy of diazepam under conditions of phenobarbital induction [2]. This finding may be related to alteration of the functional state of the GABA-benzodiazepine-ionophore complex.…”

“…Under the same conditions the activity of antidotes was also enhanced [2]. A protective effect of perfluorocarbons was demonstrated against the background of poisoning with organophosphorus compounds [3].…”

“…Previously an increase of resistance to the toxic action of organophosphorus compounds [8] and GABA-lytics [2] was noted for rodents for preliminary barbiturate administration. Under the same conditions the activity of antidotes was also enhanced [2].…”

“…Benzonal and phenobarbital have been found to raise resistance to the toxic gamma-arninobutyric acid (GABA)-lytic action of picrotoxin and bicuculline when preinjected 3 times to mice [2]. The antidotal activity of diazepam was enhanced under these conditions.…”

Effect of salicylates on the toxicity of GABA-lytics in mice

“…Preparation of the membranes and the procedure of radioligand assay were described previously [1,2]. The reliability of the differences between compared parameters was evaluated using the Student t test.…”