N-linked glycosylation of PD-L1/PD-1: an emerging target for cancer diagnosis and treatment
Zhiyun Duan,
Runhan Shi,
Bo Gao
et al.
Abstract:During tumorigenesis and progression, the immune checkpoint programmed death-1 (PD-1) and its ligand programmed death ligand-1 (PD-L1) play critical roles in suppressing T cell-mediated anticancer immune responses, leading to T-cell exhaustion and subsequent tumor evasion. Therefore, anti-PD-L1/PD-1 therapy has been an attractive strategy for treating cancer over the past decade. However, the overall efficacy of this approach remains suboptimal, revealing an urgent need for novel insights. Interestingly, incre… Show more
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