N-isopropyl-p-[I-123]lodoamphetamine Lung Imaging in a Patient with Chronic Pulmonary Thromboembolism

Kosuda, Shigeru; Kawahara, Shunji; Tamura, Kohei; Ishikawa, N.; Ono, Akifumi; Kubo, Atsushi; Hashimoto, S

doi:10.1097/00003072-198910000-00008

Cited by 4 publications

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“…[33][34][35] The washout rate from liver cirrhosis was faster than normal liver parenchyma. This is assumed to be due to a decrease in the cellularity of the liver parenchyma in liver cirrhosis.…”

Section: Hepatic Neoplasmsmentioning

confidence: 99%

Intra-arterial infusion of N-isopropyl-p[123I]iodoamphetamine for assessing effective blood supply to pulmonary and hepatic neoplasms

Miyazaki

1994

Ann Nucl Med

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The biodistribution and pharmacokinetics of intra-arterially administered N-isopropyl-p[123I] iodoamphetamine (123I-IMP) were prospectively evaluated in 38 patients with histologically proven pulmonary or hepatic tumors. Intra-arterially infused 123I-IMP was distributed initially in peripheral tissues in which the blood supply was maintained. Its concentration in malignant neoplasms was demonstrated to be higher than in normal tissues. In pulmonary cancer, the tumor uptake of the administered dose without a tissue attenuation correction (% uptake) of 123I-IMP at 1-2 min after injection was 14.7 +/- 5.7% (s.d.). The tumor to normal tissue ratio was 2.1 +/- 0.7 in hepatocellular carcinoma and 1.4 +/- 0.7 in metastatic tumors. The biodistribution of 123I-IMP was also compared to that of 99mTc-macroaggregated albumin (99mTc-MAA) in 9 cases of hepatic cancer. The distribution of 123I-IMP resembled that of 99mTc-MAA in 5 cases and was different in 4 cases. 123I-IMP was more concentrated in the tumor than 99mTc-MAA. Intra-arterial infusion scintigraphy with 123I-IMP seems to provide information on effective blood supply to neoplasms which are targeted in interventional radiology.

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Section: Hepatic Neoplasmsmentioning

confidence: 99%

Intra-arterial infusion of N-isopropyl-p[123I]iodoamphetamine for assessing effective blood supply to pulmonary and hepatic neoplasms

Miyazaki

1994

Ann Nucl Med

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On clinical usefulness of Tl-201 scintigraphy for the management of malignant soft tissue tumors

et al. 1994

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The purpose of this study was to investigate Tl-201 as a tumor scanning agent in patients with malignant soft tissue sarcomas and to establish the sensitivity of this type of scintigraphy concerning local recurrences or metastases that may remain clinically suspected. Seventy-eight patients with malignant soft tissue sarcomas and 22 with benign soft tissue tumors were studied. Of these 78 malignant soft tissue sarcomas patients, the sensitivity of Tl-201 (81.2%) was higher than that of Ga-67 (68.8%). Thirty-three out of 78 patients received a total of 95 consecutive scintigraphic follow-up examinations. Therapeutic effects was assessed by comparing the results of Tl-201 examinations with the clinical findings. Of these 33 patients, the therapeutic effects observed were as follows: complete remission 1, partial remission 8, progress of disease 1, and no remarkable change 23. Tl-201 scintigraphy has proved itself very useful not only in clinically detecting the malignant soft tissue sarcomas and in assessing therapeutic effects on these diseases, but also in assessing the follow-up patients with malignant soft tissue sarcomas.

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I-123 IMP scintigraphy in two patients with primary pulmonary malignant lymphoma

Suga

1994

Ann Nucl Med

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123I-IMP lung scintigraphy was performed in two patients with primary malignant lymphoma, whose radiographic features were difficult to differentiate from inflammatory or atelectatic lesions. 123I-IMP scans revealed a defect in the lesions on the delayed (24 hr) image, suggesting a tumorous lesion. 123I-IMP scan may contribute to differential diagnosis of this rare tumorous entity from benign disorders having a different appearance.

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N-isopropyl-p-[I-123]lodoamphetamine Lung Imaging in a Patient with Chronic Pulmonary Thromboembolism

Cited by 4 publications

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Intra-arterial infusion of N-isopropyl-p[123I]iodoamphetamine for assessing effective blood supply to pulmonary and hepatic neoplasms

Intra-arterial infusion of N-isopropyl-p[123I]iodoamphetamine for assessing effective blood supply to pulmonary and hepatic neoplasms

On clinical usefulness of Tl-201 scintigraphy for the management of malignant soft tissue tumors

I-123 IMP scintigraphy in two patients with primary pulmonary malignant lymphoma

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