N-hydroxysulfamides as analog ofN-hydroxyurea: synthesis and biological evaluation

Sulfamic Acid and Its N- and O-Substituted Derivatives

“…Compound 476 ( n = 1, R = −C 6 H 4 SO 2 NH 2 - p ) and some closely related compounds have been patented as hypoglycemic agents to lower blood sugar levels, and the same group reported compounds such as 476 ( n = 1, 2, 3, R = NH 2 , 1-piperidinyl, morpholino, 1-pyrrolidinyl, substituted amino) for similar usage . A series of N -hydroxysulfamides BocNHSO 2 NHR (R = H, OtBu, OBn, – OHN + Et 3 ) has been synthesized and their antifungal, antiviral, and antiproliferative activities assessed …”