Abstract:Objectives: The study aims to examine the anticancer effect of polyisoprenoid of Nypa fruticans, Ceriops tagal, and Rhizophora mucronata leaves in WiDr cells by evaluating the regulation of p21 and Akt 2 gene.
Design: Nypa fruticans, Ceriops tagal, and Rhizophora mucronata leaves were dried and extracted with n-hexane, analyzed the increase or decrease in regulation of p21 gene and Akt 2 expression which was determined the Reverse Transcription Polymerase Chain Reaction (RT-PCR) method.
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