N-hexacosanol ameliorates streptozotocin-induced diabetic rat nephropathy

Saito, Motoaki; Kinoshita, Yukako; Satoh, Itaru; Shinbori, Chiko; Kono, Tomoharu; Hanada, Takuya; Uemasu, Jiro; Suzuki, Hiroto; Yamada, Masashi; Satoh, Keisuke

doi:10.1016/j.ejphar.2006.06.001

Cited by 20 publications

(11 citation statements)

References 24 publications

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“…Many studies have shown that fatty alcohols also reduce the TNF-α production in both in vitro and in vivo [11,40]. Together, our results show that the octacosanol inhibited the influx of total leukocytes into the pleural cavity triggered by carrageenan, due to the inhibition of neutrophils recruitment.…”

Section: Resultssupporting

confidence: 69%

Antinociceptive and Anti-Inflammatory Effects of Octacosanol from the Leaves of Sabicea grisea var. grisea in Mice

Oliveira

Conserva

Ferro

et al. 2012

IJMS

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Sabicea species are used in the Amazon for treatment of fever and malaria, which suggests that its chemical constituents may have some effect on pain and inflammation. Phytochemical analysis of the hexane fraction obtained from the crude ethanol extract from Sabicea grisea var. grisea Cham. & Schltdl (Rubiaceae), an endemic plant in Brazil, resulted in the isolation of octacosanol. This study investigated the antinociceptive and anti-inflammatory effects of the octacosanol in different experimental models. The crude ethanolic extract and hexane fraction obtained from the leaves of S. grisea produced an inhibition of acetic acid-induced pain. Moreover, octacosanol isolated from the hexane fraction produced a significant inhibition of pain response elicited by acetic acid. Pre-treatment with yohimbine, an alpha 2-adrenergic receptor antagonist, notably reversed the antinociceptive activity induced by octacosanol in the abdominal constriction test. Furthermore, mice treated with octacosanol did not exhibit any behavioral alteration during the hot plate and rota-rod tests, indicating non-participation of the supraspinal components in the modulation of pain by octacosanol with no motor abnormality. In the formalin test, octacosanol did not inhibit the licking time in first phase (neurogenic pain), but significantly inhibited the licking time in second phase (inflammatory pain) of mice. The anti-inflammatory effect of octacosanol was evaluated using carrageenan-induced pleurisy. The octacosanol significantly reduced the total leukocyte count and neutrophils influx, as well as TNF-α levels in the carrageenan-induced pleurisy. This study revealed that the mechanism responsible for the antinociceptive and anti-inflammatory effects of the octacosanol appears to be partly associated with an inhibition of alpha 2-adrenergic transmission and an inhibition of pathways dependent on pro-inflammatory cytokines. Finally, these results demonstrated that the octacosanol from the leaves of S. grisea possesses antinociceptive and anti-inflammatory activities, which could be of relevance for the pharmacological control of pain and inflammatory processes.

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Section: Resultssupporting

confidence: 69%

Antinociceptive and Anti-Inflammatory Effects of Octacosanol from the Leaves of Sabicea grisea var. grisea in Mice

Oliveira

Conserva

Ferro

et al. 2012

IJMS

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“…Hexacosanol has also been shown to decrease cytokine concentrations in the kidney of streptozotocin-induced diabetic rats [37]. In fact, Muller et al [38] reported that synthetic LCFAs, bearing an α-tocopherol moiety, reduce TNF-α secretion by LPSactivated microglia.…”

Section: Discussionmentioning

confidence: 97%

Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediators

Fernández-Arche

Márquez-Martín

Vázquez

et al. 2009

The Journal of Nutritional Biochemistry

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Pomace olive oil is a by-product of olive oil extraction that is traditionally produced and consumed in Spain. The nonglyceride matter of this oil is a good source of interesting minor compounds, like long-chain fatty alcohols, which are present free or as part of waxes. In the present study, long-chain fatty alcohols were isolated from the nonglyceride fraction of pomace olive oil, and the composition was identified and quantified. The major components of long-chain fatty alcohols were tetracosanol, hexacosanol and octacosanol. We investigated the ability of long-chain fatty alcohols from pomace olive oil to inhibit the release of different proinflammatory mediators in vitro by cells involved in inflammatory processes. Long-chain fatty alcohols significantly and dose-dependently decreased nitric oxide production by RAW 264.7 murine macrophages stimulated with lipopolysaccharide. Western blot analysis showed that nitric oxide reduction was a consequence of the inhibition of inducible nitric oxide synthetase expression. Long-chain fatty alcohols also reduced tumor necrosis factor-alpha and prostaglandin E(2) production, although the potency of inhibition for the latter was lower. On the other hand, long-chain fatty alcohols significantly reduced thromboxane A(2) production in rat peritoneal neutrophils stimulated with the calcium ionophore A-23187. The reduction of eicosanoid release was related to the inhibition of phospholipase A(2) enzyme activity by long-chain fatty alcohols, reaching an inhibitory concentration 50% value of 6.2 microg/ml. These results showed that long-chain fatty alcohols may have a protective effect on some mediators involved in the inflammatory damage development, suggesting its potential value as a putative functional component of pomace olive oil.

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“…SPSS version 15.0 SPSS Inc., Chicago, IL, U.S.A. was used to determine the significant differences and for cluster analysis. Principal component analysis PCA was performed on all samples using the software XLSTAT version 2009. n-hexacosanol 2 and 8 mg/Kg did not alter rats 8-week diabetic status, including body weight, serum glucose levels, serum insulin levels, and urine output, but it did significantly improve serum creatinine levels and urinary albumin levels, and it inhibited the increase in kidney weight 41 .…”

Section: Discussionmentioning

confidence: 99%

Policosanol in Tomato (<i>Solanum lycopersicum</i> L.) Seed Oil: the Effect of Cultivar

Giuffré

Capocasale

2015

J. Oleo Sci.

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N-hexacosanol ameliorates streptozotocin-induced diabetic rat nephropathy

Cited by 20 publications

References 24 publications

Antinociceptive and Anti-Inflammatory Effects of Octacosanol from the Leaves of Sabicea grisea var. grisea in Mice

Antinociceptive and Anti-Inflammatory Effects of Octacosanol from the Leaves of Sabicea grisea var. grisea in Mice

Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediators

Policosanol in Tomato (<i>Solanum lycopersicum</i> L.) Seed Oil: the Effect of Cultivar

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