2017
DOI: 10.1007/s10593-017-2047-3
|View full text |Cite
|
Sign up to set email alerts
|

N-(Hetero)aryl-2-imidazolines: an emerging privileged motif for contemporary drug design

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
7
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 13 publications
(9 citation statements)
references
References 48 publications
1
7
0
Order By: Relevance
“…The application of 15 In the case of the reaction between azirine derivative 146* and phthalimide, the tricyclic product 153* 57 was isolated. The structure of 153* was identied by measurements of 13 C-15 N SSCCs ( 1 J C9b-N2 ¼ 7 Hz and 1 J C3-N2 ¼ 8 Hz), which were registered for sp 3 -hybridized carbon atoms (Scheme 41). Additionally, the 1 J HN -couplings were not detected in the 1D 1 H and 15 N NMR spectra.…”
Section: Analysis Of J Cn and J Hn Couplings In The Study Of Other Rimentioning
confidence: 99%
See 1 more Smart Citation
“…The application of 15 In the case of the reaction between azirine derivative 146* and phthalimide, the tricyclic product 153* 57 was isolated. The structure of 153* was identied by measurements of 13 C-15 N SSCCs ( 1 J C9b-N2 ¼ 7 Hz and 1 J C3-N2 ¼ 8 Hz), which were registered for sp 3 -hybridized carbon atoms (Scheme 41). Additionally, the 1 J HN -couplings were not detected in the 1D 1 H and 15 N NMR spectra.…”
Section: Analysis Of J Cn and J Hn Couplings In The Study Of Other Rimentioning
confidence: 99%
“…Nitrogen heterocycles are a ubiquitous class of organic compounds that include azirine, azetidine, azole, azine and azepine derivatives and their fused analogs. These structures are inherent in drug design [1][2][3][4][5][6][7] and natural compounds, 8,9 in catalysis for cross-coupling and asymmetric synthesis reactions, 10,11 in materials science as metal complexes with luminescent properties, [12][13][14] in ligands for the separation of lanthanides 15 and in high-density energy materials. 16,17 At rst glance, it seems that establishing the structure of poly-nitrogen-containing compounds can be achieved by general NMR methods suitable for carbon-containing compounds; however, this statement is not correct.…”
Section: Introductionmentioning
confidence: 99%
“…Imidazolines are a class of compounds of strong interest in pharmacy 1,2 and medicine 3,4 which is continuously enhanced by new developments, as for example for imaging 5,6 and antibacterial 7 purposes. Similarly, their established industrial significance 8,9 has been recently reinforced by new applications as ligands for enantioselective catalysis 10 as well as corrosion additives.…”
Section: Introductionmentioning
confidence: 99%
“…Not surprisingly, imidazalines are oen regarded nowadays as one of the privileged scaffolds for drug discovery. 11,12 Normally, preparation of 2-imidazolines 4 is very straightforward and involves acylation of 1,2-diamines 2 with carbonyl compounds 1 (acyl, thioacyl, carbamoyl halides, esters, carboxylic acids, or nitriles) and subsequent cyclocondensation of the formed b-aminocarboxamide intermediate 3 (Scheme 1). [13][14][15][16] For number of years we were interested in electrophilic activation of nitroalkanes and their reactions with different nucleophilic species.…”
Section: Introductionmentioning
confidence: 99%