N-glycosylation as a Modulator of Protein Conformation and Assembly in Disease
Chiranjeevi Pasala,
Tanaya Roychowdhury,
Sahil Sharma
et al.
Abstract:Glycosylation, a prevalent post-translational modification, plays a pivotal role in regulating intricate cellular processes by covalently attaching glycans to macromolecules. Dysregulated glycosylation is linked to a spectrum of diseases, encompassing cancer, neurodegenerative disorders, congenital disorders, infections, and inflammation. This review delves into the intricate interplay between glycosylation and protein conformation, with a specific focus on the profound impact of N-glycans on the selection of … Show more
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