N-Glycan and O-Glycan Glycosylation in Eukaryotes

Kim, Cheorl-Ho

doi:10.1007/978-981-15-5815-3_2

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…The glycosylation process begins with the quality control of a protein within the ER, which is the first section of the secretory pathway to check and mature the related proteins that are supposed to be glycosylated. On the other hand, the GA has been recognized as the leading center for glycosylation [22]. Indeed, the GA, recognized as the central hub of the cellular secretory machinery system, is made of different cisternae comprising the cis-Golgi network, cis, medial, trans, and trans-Golgi network with their topological characteristics and structures (Figure 1).…”

Section: Glycosylationmentioning

confidence: 99%

Candida albicans: Pathogenesis and Secretory Pathways

Afzelius,

Proestos,

Behzadi

2024

Candida Albicans - Epidemiology and Treatment [Working Title]

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Candida albicans is a member of the human host’s microbiome composition; therefore, it is recognized as a portion of the human host body’s normal flora in a homeostasis condition. However, when the host develops an abnormal condition, e.g., immune deficiency, C. albicans acts as an opportunistic pathogen. C. albicans has an effective arsenal of a wide range of virulence factors. Due to this knowledge, the enzymes construct a significant portion of substantial fungal virulence factors, which are made of proteins and play an essential role in fungal invasion, fungal-hyphal growth, and biofilm formation. An active secreted protein should be processed via the fungal secretion system, such as the endoplasmic reticulum (ER) and/or Golgi apparatus (GA). In other words, an active protein that acts as a fungal virulence factor should undergo several vital and pivotal maturation processes, including glycosylation and folding. In this chapter, we have a rigorous look at these processes, which directly determine the pathogenesis of C. albicans.

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Section: Glycosylationmentioning

confidence: 99%