Abstract:Oxidized cysteine residues are highly reactive and may form covalent conjugates with other residues in proteins to enable proper functionalities, for example, the lysine-cysteine NOS bridge identified recently as an allosteric redox switch. To our knowledge, the NOS-covalent species per se directly engaging in reactions has not been previously demonstrated. Here, we report a non-canonical FAD-dependent enzyme Orf1 that adds a glycine-derived N-formimidoyl group to glycinothricin forming BD-12, an enzymatic pro… Show more
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