N-cystaminylbiguanide MC001 prevents neuron cell death and alleviates motor deficits in the MPTP-model of Parkinson’s disease

Xu, Binlin; Wang, Xiaoquan; Xu, Zhengshuang; Li, Qinkai; Quan, Jing

doi:10.1016/j.neulet.2022.136751

Cited by 1 publication

(1 citation statement)

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“…Zhao et al showed that baicalein-treated mice exhibited lower depression-based symptoms after a monthly treatment, and its repeated usage induced α-synuclein dissociation, neuroinflammation blockage, and regulating the homeostasis of neurotransmitters ( Zhao et al, 2021 ). In another study, Song et al investigated that baicalein can also inhibit the MAO enzyme, and its blocking action on oxidative stress is governed by ERK inhibition in PD ( Song et al, 2021 ; Xu et al, 2022 ).…”

Section: Phytoconstituents In Different Neurological Disordersmentioning

confidence: 99%

Natural product-based pharmacological studies for neurological disorders

Puri

Kanojia²,

Sharma³

et al. 2022

Front. Pharmacol.

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Central nervous system (CNS) disorders and diseases are expected to rise sharply in the coming years, partly because of the world’s aging population. Medicines for the treatment of the CNS have not been successfully made. Inadequate knowledge about the brain, pharmacokinetic and dynamic errors in preclinical studies, challenges with clinical trial design, complexity and variety of human brain illnesses, and variations in species are some potential scenarios. Neurodegenerative diseases (NDDs) are multifaceted and lack identifiable etiological components, and the drugs developed to treat them did not meet the requirements of those who anticipated treatments. Therefore, there is a great demand for safe and effective natural therapeutic adjuvants. For the treatment of NDDs and other memory-related problems, many herbal and natural items have been used in the Ayurvedic medical system. Anxiety, depression, Parkinson’s, and Alzheimer’s diseases (AD), as well as a plethora of other neuropsychiatric disorders, may benefit from the use of plant and food-derived chemicals that have antidepressant or antiepileptic properties. We have summarized the present level of knowledge about natural products based on topological evidence, bioinformatics analysis, and translational research in this review. We have also highlighted some clinical research or investigation that will help us select natural products for the treatment of neurological conditions. In the present review, we have explored the potential efficacy of phytoconstituents against neurological diseases. Various evidence-based studies and extensive recent investigations have been included, which will help pharmacologists reduce the progression of neuronal disease.

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Section: Phytoconstituents In Different Neurological Disordersmentioning

confidence: 99%