2001
DOI: 10.1001/archotol.127.5.530
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N-Chlorotaurine, a Novel Endogenous Antimicrobial Agent

Abstract: Objective: To investigate the tolerability of Nchlorotaurine, a new antimicrobial agent, by application to the middle ear in a mouse model. Methods:Five BALB/c mice were each injected through the tympanic membrane with 5 µL of 0.1%, 1.0%, and 10% N-chlorotaurine and compared with animals in which 0.9% isotonic sodium chloride solution, 0.2% gentamicin sulfate, and 0.25% trimethyltin chloride were instilled. Auditory brainstem responses to clicks were evaluated repeatedly between 4 and 75 days after injection, … Show more

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Cited by 15 publications
(9 citation statements)
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References 21 publications
(23 reference statements)
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“…In clinical studies evaluating NCT, no adverse effects were observed when treating cystitis or conjunctivitis except for mild eye burning or eye itching 25,26 . When applied to the middle ear of the mouse, 1% NCT caused a little local irritation and a healing delay of the artificial defect of the tympanic membrane, but no residual defect was found 28 …”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…In clinical studies evaluating NCT, no adverse effects were observed when treating cystitis or conjunctivitis except for mild eye burning or eye itching 25,26 . When applied to the middle ear of the mouse, 1% NCT caused a little local irritation and a healing delay of the artificial defect of the tympanic membrane, but no residual defect was found 28 …”
Section: Discussionmentioning
confidence: 98%
“…The same was true for urinary tract infections caused by omniresistant P. aeruginosa , where NCT demonstrated rapid bactericidal activity, 26 and it was able to eradicate this pathogen in a case of localized cystitis 27 . In a mouse model, NCT was applied to the middle ear without severe side‐effects 28 . Because of these encouraging findings we compared in the present double‐blind, randomized phase IIb study the clinical efficacy and tolerability of the new compound NCT with CAT in bacterially contaminated chronic leg ulcers with purulent coatings.…”
mentioning
confidence: 97%
“…An efficient treatment of otitis externa could be achieved using N‐chlorotaurine (NCT), an endogenous antimicrobial agent that is currently under investigation for topical application of various infections at our university. 5–9 The substance is an endogenous, long‐lived oxidant normally generated by leukocytes during inflammation, 10–13 and it has microbicidal activity against gram‐positive and gram‐negative bacteria and fungi including the above‐mentioned pathogens. 14–17 …”
Section: Introductionmentioning
confidence: 99%
“…The only side effect was a delay of healing of an artificial perforation of the tympanic membrane, which was used for the application of the agent. 9 …”
Section: Introductionmentioning
confidence: 99%
“…An efficient treatment of rhinosinusitis could be achieved using N-chlorotaurine (NCT), an endogenous antimicrobial agent which is currently under investigation for topical application of various infections at our university [4][5][6][7][8].…”
Section: Introductionmentioning
confidence: 99%