N-Cadherin Mimetic Peptide Nanofiber System Induces Chondrogenic Differentiation of Mesenchymal Stem Cells

Çimenci, Çağla Eren; Kurtulus, Gozde Uzunalli; Çalışkan, Özüm Şehnaz; Güler, Mustafa O.; Tekinay, Ayşe B.

doi:10.1021/acs.bioconjchem.9b00514

Cited by 25 publications

(18 citation statements)

References 37 publications

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“…[ 9b ] C) N‐cadherin mimetic peptide nanofiber hydrogel and KLD12 hydrogel are able to enhance cell‐to‐cell interactions by a tissue‐specific modeling strategy to support mesenchymal stem cells (MSC) commitment into the chondrogenic lineage. [ 171,217 ] D) Arg‐Gly‐Asp‐Ser (RGDS)‐modified peptide amphiphile (PA) hydrogel generate a type of instructive cell construct for the epidermis, neovascularization, and proliferation of fibroblasts. [ 218 ] E) Functionalized EAK16‐II hydrogels offer the tools to inject or dab the tissue‐specific cell construct onto intestinal areas affected by loss of loconeurons to treat the gastrointestinal disorders caused by the lack of specific neuronal subpopulations.…”

Section: Instructive Cell Constructs In Tissue Engineering and Precismentioning

confidence: 99%

Designer Self‐Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer

Yang

Zhao

2020

Advanced Science

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mouse intestinal stem cells and primary colorectal cancer cells can be propagated in vitro long term, [1] there is an urgent need to develop more physiologically relevant, efficient, and robust precise oncology models that closely recapitulate the genetic and morphological heterogeneous composition and mimic the arrangement pattern of cancer cells in the original tumor. [2] To our knowledge in biomedical research, hydrogel is the best tool to reconstruct precise oncology models in vitro, especially tumor organoid, which not only recapitulates in vivo biology and microenvironmental factors, but also at large extent allows side-by-side comparison to evaluate the translational potential of 3D model systems to the patients. [2a,3] Generally, hydrogels are mainly composed of hydrophilic polymeric scaffolds that absorb large amounts of water, so the hydrogel matrix better mimics elastic and viscoelastic properties in ECM and microscale topographies of cell matrices, which controls proper cell morphology, directs viable cell behaviors, and drives in vivo fundamental cell-cell or cell-ECM interactions. [4] To recapitulate pathophysiological features of human tumors and imitate various aspects of human tumorigenesis in vivo, hydrogels can provide a realistic platform to establish a useful bridge between in vitro assays and in vivo cell microenvironments. In current biomedical applications, there are many kinds of hydrogels to be developed to mimic the biological properties of ECM, such Designer self-assembling peptides form the entangled nanofiber networks in hydrogels by ionic-complementary self-assembly. This type of hydrogel has realistic biological and physiochemical properties to serve as biomimetic extracellular matrix (ECM) for biomedical applications. The advantages and benefits are distinct from natural hydrogels and other synthetic or semisynthetic hydrogels. Designer peptides provide diverse alternatives of main building blocks to form various functional nanostructures. The entangled nanofiber networks permit essential compositional complexity and heterogeneity of engineering cell microenvironments in comparison with other hydrogels, which may reconstruct the tumor microenvironments (TMEs) in 3D cell cultures and tissue-specific modeling in vitro. Either ovarian cancer progression or recurrence and relapse are involved in the multifaceted TMEs in addition to mesothelial cells, fibroblasts, endothelial cells, pericytes, immune cells, adipocytes, and the ECM. Based on the progress in common hydrogel products, this work focuses on the diverse designer self-assembling peptide hydrogels for instructive cell constructs in tissue-specific modeling and the precise oncology remodeling for ovarian cancer, which are issued by several research aspects in a 3D context. The advantages and significance of designer peptide hydrogels are discussed, and some common approaches and coming challenges are also addressed in current complex tumor diseases.

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Section: Instructive Cell Constructs In Tissue Engineering and Precismentioning

confidence: 99%

Designer Self‐Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer

Yang

Zhao

2020

Advanced Science

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“…The different types of N-, P-, R-, B- and E−cadherins all play important roles in tissue formation and signal cascade regulation [ 116 , 117 ]. N-cadherins play an essential role for mesenchymal cell condensation during chondrogenesis through mediating the aggregation of progenitor cells and promoting cell-to-cell interactions [ 118 ].…”

Section: Bioactive Peptide To Promote Chondrogenesismentioning

confidence: 99%

Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering

Zhu

Zhong

Cao

et al. 2022

Bioactive Materials

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The repair of articular cartilage defects is still challenging in the fields of orthopedics and maxillofacial surgery due to the avascular structure of articular cartilage and the limited regenerative capacity of mature chondrocytes. To provide viable treatment options, tremendous efforts have been made to develop various chondrogenically-functionalized biomaterials for cartilage tissue engineering. Peptides that are derived from and mimic the functions of chondroconductive cartilage extracellular matrix and chondroinductive growth factors, represent a unique group of bioactive agents for chondrogenic functionalization. Since they can be chemically synthesized, peptides bear better reproducibility, more stable efficacy, higher modifiability and yielding efficiency in comparison with naturally derived biomaterials and recombinant growth factors. In this review, we summarize the current knowledge in the designs of the chondroinductive/chondroconductive peptides, the underlying molecular mechanisms and their-functionalized biomaterials for cartilage tissue engineering. We also systematically compare their in-vitro and in-vivo efficacies in inducing chondrogenesis. Our vision is to stimulate the development of novel peptides and their-functionalized biomaterials for cartilage tissue engineering.

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“…The fibers promoted viability and cell adhesion and enhanced the expression of cartilage matrix components. [ 145 ]…”

Section: Biomaterials That Mimic Cell–cell Interactionsmentioning

confidence: 99%

You Talking to Me? Cadherin and Integrin Crosstalk in Biomaterial Design

Barcelona‐Estaje

Dalby

Cantini

et al. 2021

Adv Healthcare Materials

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While much work has been done in the design of biomaterials to control integrin‐mediated adhesion, less emphasis has been put on functionalization of materials with cadherin ligands. Yet, cell–cell contacts in combination with cell–matrix interactions are key in driving embryonic development, collective cell migration, epithelial to mesenchymal transition, and cancer metastatic processes, among others. This review focuses on the incorporation of both cadherin and integrin ligands in biomaterial design, to promote what is called the “adhesive crosstalk.” First, the structure and function of cadherins and their role in eliciting mechanotransductive processes, by themselves or in combination with integrin mechanosensing, are introduced. Then, biomaterials that mimic cell–cell interactions, and recent applications to get insights in fundamental biology and tissue engineering, are critically discussed.

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N-Cadherin Mimetic Peptide Nanofiber System Induces Chondrogenic Differentiation of Mesenchymal Stem Cells

Cited by 25 publications

References 37 publications

Designer Self‐Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer

Designer Self‐Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer

Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering

You Talking to Me? Cadherin and Integrin Crosstalk in Biomaterial Design

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