N-Butyl-2-Cyanoacrylate (Histoacryl) Plus Sclerotherapy Versus Sclerotherapy Alone in the Treatment of Bleeding Esophageal Varices: a Randomized Prospective Study

Feretis, Christos; Dimopoulos, C.; Benakis, P.; Kalliakmanis, V; Apostolidis, Nikolaos

doi:10.1055/s-2007-1005713

Cited by 59 publications

(23 citation statements)

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“…Soehendra et al [17,18] had only a 5.5% recurrent bleeding rate using this agent and no recurrent bleeding within 30 days of treatment. More recent studies have shown similar results [19,20]. A randomized, controlled study of various sclerotherapy agents conducted in canines showed that cyanoacrylate was superior to sodium tetradecyl sulfate, ethanol, sodium morrhuate, polidocanol, and epinephrine in terms of immediate efficacy, low-volume requirement, time to initial hemostasis, and size reduction of varices [21].…”

Section: Gastric Varicesmentioning

confidence: 83%

Extraesophageal Varices

Kotfila¹,

Trudeau²

1998

Dig Dis

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Esophageal varices are the most common site of variceal bleeding. However, bleeding from varices that are not located in the esophagus may account for up to 30% of all variceal bleeding. Significant varices can occur in the stomach, duodenum, jejunum, ileum, colon, rectum, and biliary tree. They can also occur at the site of a surgical ostomy. These types of varices bleed less commonly than esophageal varices, but they can also be far more difficult to diagnose and treat. The absence of stigmata of recent esophageal variceal bleeding and certain clues in the patient’s history and clinical presentation should raise the clinician’s suspicion of an extraesophageal site of variceal bleeding. Particularly, patients with extrahepatic causes of portal hypertension, cirrhotic patients with a prior history of gastrointestinal surgery, and patients who present with profound bleeding but without hematemesis need to be evaluated further if an obvious site of esophageal variceal bleeding is not seen on initial endoscopy. In this article, we review the features particular to extraesophageal varices as well as the diagnosis and management of bleeding from these varices. We use the term extraesophageal rather than ectopic because the term ectopic varices implies exclusion of both esophageal and gastric varices.

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Section: Gastric Varicesmentioning

confidence: 83%

Extraesophageal Varices

Kotfila¹,

Trudeau²

1998

Dig Dis

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“…Ideally, the sclerotherapy needle should be carefully placed within the varix prior to injection, to avoid leak of the adhesive [84] . Two randomised controlled trials compared sclerotherapy alone with the combination of sclerotherapy and Histoacryl for the control of active variceal bleeding [85,86] . The combined treatment was more effective than sclerotherapy alone in both studies.…”

Section: Randomized Controlled Trials Of Tissue Adhesives In the Manamentioning

confidence: 99%

Acute variceal bleeding: general management

Patch

Dagher²

2001

WJG

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“…www.wjgnet.com e m b o l i s m , p o r t a l v e i n e m b o l i s m a n d s p l e n i c infarction [13,14] . Gastric varices are characterized by an enlarged caliber of the vessel bed, large draining veins and rapid blood flow, which may exacerbate the situation.…”

Section: B Cmentioning

confidence: 99%

Successful endoscopic sclerotherapy for bleeding gastric varices with combined cyanoacrylate and aethoxysklerol

Shi¹,

Wu²,

Zhu³

et al. 2008

WJG

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Two patients with liver cirrhosis and portal hypertension related to hepatitis infection were admitted to Shanghai Ruijin Hospital due to recurrent melena and hematemesis. Isolated gastric varices were observed in the gastric fundus during the retroflexion of gastroscope. We carried out endoscopic sclerotherapy successfully for bleeding gastric varices with combined cyanoacrylate and aethoxysklerol, which disappeared dramatically several months after two courses of sclerotherapy for each patient. No complication and clinical signs of gastrointestinal re-bleeding were observed during the 6-mo endoscopic follow-up. CT portal angiography (CTPA) has been widely used in the assessment of variceal treatment and improves the results of endoscopic injection therapy.

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N-Butyl-2-Cyanoacrylate (Histoacryl) Plus Sclerotherapy Versus Sclerotherapy Alone in the Treatment of Bleeding Esophageal Varices: a Randomized Prospective Study

Abstract: The combination of Histoacryl with conventional sclerotherapy with polidocanol in patients with esophageal bleeding who present with active bleeding, at the initial injection therapy, can improve the results of endoscopic management.

Cited by 59 publications

References 0 publications

Extraesophageal Varices

Extraesophageal Varices

Acute variceal bleeding: general management

Successful endoscopic sclerotherapy for bleeding gastric varices with combined cyanoacrylate and aethoxysklerol

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