“…3–13 Likewise, Shanmugaraju and co-workers have recently developed several excellent examples of naphthalimide Tröger's bases and demonstrated their application in a range of supramolecular chemistry applications. 14–18 Ru( ii ) polypyridyl complexes are known DNA and RNA targeting agents, but biological profiling of such complexes has only recently been appreciated and studied in some detail. 19–28 Hence, the pursuit of Ru( ii ) polypyridyl complexes as cellular imaging agents and potential theranostics is gathering pace with the recent progression of the thiophane containing TLD1433 to a phase II study for treating non-muscle invasive bladder cancer – the first ruthenium polypridyl based PDT agent to progress to clinical trials.…”
Ru(ii)-Polypyridyl-1,8-naphthalimide Tröger's bases have undergone detailed biological profiling to unravel their mechanism of cellular uptake, cellular trafficking and cellular responses to photoexcitation.
“…3–13 Likewise, Shanmugaraju and co-workers have recently developed several excellent examples of naphthalimide Tröger's bases and demonstrated their application in a range of supramolecular chemistry applications. 14–18 Ru( ii ) polypyridyl complexes are known DNA and RNA targeting agents, but biological profiling of such complexes has only recently been appreciated and studied in some detail. 19–28 Hence, the pursuit of Ru( ii ) polypyridyl complexes as cellular imaging agents and potential theranostics is gathering pace with the recent progression of the thiophane containing TLD1433 to a phase II study for treating non-muscle invasive bladder cancer – the first ruthenium polypridyl based PDT agent to progress to clinical trials.…”
Ru(ii)-Polypyridyl-1,8-naphthalimide Tröger's bases have undergone detailed biological profiling to unravel their mechanism of cellular uptake, cellular trafficking and cellular responses to photoexcitation.
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