N‐ and C‐Acyclic Thionucleoside Analogues of 1,2,3‐Triazole.

Abstract

Nucleic acids U 0700N-and C-Acyclic Thionucleoside Analogues of 1,2,3-Triazole. -1,3-Dipolar cycloaddition of azide (II) with butyne leads to the title nucleoside analogue (IV) which is used for further derivatization. -(AL-MASOUDI*, N. A.; AL-SOUD, Y. A.; ABDUL-ZAHRA, A.; Heteroat. Chem. 15 (2004) 5, 380-387; Fachbereich Chem., Univ. Konstanz, D-78434 Konstanz, Germany; Eng.) -M. Bohle 45-224

Nitroimidazoles, part 4: Synthesis and anti‐HIV activity of new 5‐alkylsulfanyl and 5‐(4′‐arylsulfonyl)piperazinyl‐4‐nitroimidazole derivatives

“…The 1 H NMR spectra demonstrated broad singlets, triplets, or multiplets in the region between δ H 2.89 and 3.58, attributed to the piperazine protons. The 13 C NMR spectra supported the proposed structures because the carbons of the imidazole ring were deduced by comparison with those of 5-11 and the structurally proven 5-alkylamino imidazole derivatives [33].…”

“…• C afforded the amide 6 (90%), whereas a similar treatment of 7, prepared previously in our laboratory [33] with NH 3 /MeOH, gave the thioammonium salt 10 as a result of the β-elimination of the ethyl ester group at C 5 -S group. When the acid 8 was treated with SOCl 2 at 23…”

“…The assignment of protons and carbons of the imidazole ring was deduced in comparison to compounds 5-11 and the previously reported data of 7 [33]. The structural assignment of 15 follows from the mass spectrum and the 1 H and 13 C NMR spectra.…”

“…This compound was prepared according to reference [33]. Compound 4 (1.55 g, 5.0 mmol) and methyl 3-mercaptopropanoate (0.30 g, 2.50 mmol).…”

Multinuclear magnetic resonance studies of 2‐aryl‐1,3,4‐thiadiazoles

“…The compounds containing 1,3,4-thiadiazole moiety show interesting pharmacological activities as well as properties useful from the technological and agricultural point of view. [1][2][3][4][5] Their antibacterial, [6][7][8][9][10][11] antiviral, [12][13][14][15] anticancer, [11,13,16] antiparasitic, [17][18][19] anti-inflammatory, [14] anticholinergic [7] and antihistamine [7,20] activities have been widely studied. Some compounds belonging to this class are potent radioprotective agents.…”