N-Alkyl/aryl-4-(3-substituted-3-phenylpropyl)piperazine-1-carbothioamide as dual-action vaginal microbicides with reverse transcriptase inhibition

Bala, Veenu; Mandalapu, Dhanaraju; Gupta, Sonal; Jangir, Santosh; Kushwaha, Bhavana; Chhonker, Yashpal S.; Chandasana, Hardik; Krishna, Shagun; Rawat, Kavita; Krishna, Atul; Singh, Manish Pratap; Sankhwar, Satya Narayan; Shukla, Praveen Kumar; Maikhuri, Jagdamba P.; Bhatta, Rabi Sankar; Siddiqi, Mohammad Imran; Tripathi, Renu; Gupta, Gopal; Sharma, Vishnu L.

doi:10.1016/j.ejmech.2015.07.021

Cited by 11 publications

(1 citation statement)

References 25 publications

(48 reference statements)

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“…FITC-PIP is synthesized according to the literature, 45,46 and FITC reacted with PIP by the following procedures. A sample of 10 mg of PIP and 20 mg of FITC was added to 20 mL of ethanol in a round-bottom flask at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Controllable Interfacial Polymerization for Nanofiltration Membrane Performance Improvement by the Polyphenol Interlayer

Yang

2019

ACS Omega

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It is a huge challenge to have a controllable interfacial polymerization in the fabrication process of nanofiltration (NF) membranes. In this work, a polyphenol interlayer consisting of polyethyleneimine (PEI)/tannic acid (TA) was simply assembled on the polysulfone (PSf) substrate to fine-tune the interfacial polymerization process, without additional changes to the typical NF membrane fabrication procedures. In addition, three decisive factors in the interfacial polymerization process were examined, including the diffusion kinetics of fluorescence-labeled piperazine (FITC-PIP), the spreading behavior of the hexane solution containing acyl chloride, and the polyamide layer formation on the porous substrate by in situ Fourier transform infrared (FT-IR) spectroscopy. The experimental results demonstrate that the diffusion kinetics of FITC-PIP is greatly reduced, and the spreading behavior of the hexane solution is also impeded to some extent. Furthermore, in situ FT-IR spectroscopy demonstrates that by the mitigation of this PEI/TA interlayer, the interfacial polymerization process is greatly controlled. Moreover, the as-prepared NF membrane exhibits an increased water permeation flux of 65 L m –2 h –1 (at the operation pressure of 0.6 MPa), high Na 2 SO 4 rejection of >99%, and excellent long-term structural stability.

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Section: Methodsmentioning

confidence: 99%