N‐(Alkyl)‐2‐amino‐1,4‐pyrazine Derivatives: Synthesis and Antioxidative Properties of 3‐ and 3,5‐p‐Hydroxyphenyl‐Substituted Compounds.

Abstract

Pyrazine derivativesPyrazine derivatives R 0550 N-(Alkyl)-2-amino-1,4-pyrazine Derivatives: Synthesis and Antioxidative Properties of 3-and 3,5-p-Hydroxyphenyl-Substituted Compounds. -A number of title compounds are prepared. The hydroxyphenyl substituted derivatives exhibit good antioxidative properties. Aminopyrazines bearing linear alkyl side chains of at least 6 carbon atoms show improved radical-scavenging properties in lipidic media. -(JEANJOT, P.; BRUYNEEL, F.; ARRAULT, A.; GHARBI, S.; CAVALIER, J.-F.; ABELS, A.; MARCHAND, C.; TOUILLAUX, R.; REES, J.-F.; MARCHAND-BRYNAERT*, J.; Synthesis 2003, 4, 513-522; Unite Chim. Org. Med., Univ. Cathol. Louvain, B-1348 Louvain-la-Neuve, Belg.; Eng.) -Jannicke 30-185