N-acylated chitosan: hydrophobic matrices for controlled drug release

Tien, Canh Le; Lacroix, Monique; Ispas‐Szabo, Pompilia; Mateescu, Mircea‐Alexandru

doi:10.1016/s0168-3659(03)00327-4

Cited by 289 publications

(194 citation statements)

References 38 publications

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“…The two new peaks at 1720 and 1710 cm -1 were due to C=O of -NCOR group and C=O of -OCOR group of stearoyl chitosan, which were resulted from the acylation reaction between stearoyl chloride and -NH 2 and -OH groups of chitosan [15,21]. Presence of both 1720 and 1700 cm -1 peaks confirmed that the substitution took place at both -NH2 and -OH groups in stearoyl chitosan starting from chitosan.…”

Section: Structure Characterization 321 Ft-ir Data Analysismentioning

confidence: 79%

“…The other two prominent peaks around 2920 and 2850 cm -1 were due to asymmetrical and symmetrical bending vibrations of methylene groups of long alkyl chain of stearoyl chitosan [15]. The absorption intensity was higher in stearoyl chitosan starting from deacetylated chitosan than that in stearoyl chitosan starting from chitosan.…”

Section: Structure Characterization 321 Ft-ir Data Analysismentioning

confidence: 92%

“…Two different degree substituted stearoyl chitosan compounds (DS 79%, and DS 86%) were prepared by the method described by Tien et al [15]. DS 79% stearoyl chitosan was prepared by starting chitosan (1 g) was dissolved in aqueous acetic acid (240 mL, 0.453 M) by stirring for 24 hours.…”

Section: Preparation Of Stearoyl Chitosanmentioning

confidence: 99%

“…The DS of the prepared stearoyl chitosan products (stearoyl chitosan starting from chitosan and stearoyl chitosan starting from deacetylated chitosan) were calculated by FT-IR spectroscopy [15]. According to the calculated values, the stearoyl chitosan starting from chitosan had DS 79% while stearoyl chitosan starting from deacetylated chitosan had DS 86%.…”

Section: Determination Of Dsmentioning

confidence: 99%

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Rheology and Thermal Studies of Stearoyl Chitosan Varying the Degree of Substitution

Katugampola¹,

Casson²

2017

IOSR JPTE

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Section: Structure Characterization 321 Ft-ir Data Analysismentioning

confidence: 79%

Section: Structure Characterization 321 Ft-ir Data Analysismentioning

confidence: 92%

Section: Preparation Of Stearoyl Chitosanmentioning

confidence: 99%

Section: Determination Of Dsmentioning

confidence: 99%

See 2 more Smart Citations

Rheology and Thermal Studies of Stearoyl Chitosan Varying the Degree of Substitution

Katugampola¹,

Casson²

2017

IOSR JPTE

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“…The film-forming property of chitosan has found many applications in tissue engineering and drug delivery, packaging by virtue of its mechanical strength and rather slow biodegradation [5]. Some drug-loaded chitosan films are emerging as novel drug delivery systems, and films appear to have potential for local sustained delivery of cancer chemotherapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Physical, antibacterial and antioxidant properties of chitosan films incorporated with thyme oil for potential wound healing applications

Altıok

Tıhmınlıoğlu

2010

J Mater Sci: Mater Med

318

179

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Chitosan films incorporated with thyme oil for potential applications of wound dressing were successfully prepared by solvent casting method. The water vapor permeability, oxygen transmission rate, and mechanical properties of the films were determined. Surface and crosssection morphologies and the film thicknesses were determined by Scanning Electron Microscopy (SEM). Fourier transform infrared (FT-IR) spectroscopy was conducted to determine functional group interactions between the chitosan and thyme oil. Thermal behaviors of the films were analyzed by Thermal Gravimetry (TGA) and Differential Scanning Calorimetry (DSC). In addition, the antimicrobial and the antioxidant activities of the films were investigated. The antimicrobial test was carried by agar diffusion method and the growth inhibition effects of the films including different amount of thyme oil were tested on the gram negative microorganisms of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and a gram positive microorganism of Staphylococcus aureus. The minimum thyme oil concentration in chitosan films showing the antimicrobial activity on all microorganisms used in the study was found as 1.2 % (v/v). In addition, this concentration showed the highest antioxidant activity due to mainly the carvacrol in thyme oil. Water vapor permeability and oxygen transmission rate of the films slightly increased, however, mechanical properties decreased with thyme oil incorporation. The results revealed that the thyme oil has a good potential to be incorporated into chitosan to make antibacterial and permeable films for wound healing applications.

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Polymers in Oral Modified Release Systems

Shen

Ravichandran³

et al. 2010

Oral Controlled Release Formulation Design and Drug Delivery

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N-acylated chitosan: hydrophobic matrices for controlled drug release

Cited by 289 publications

References 38 publications

Rheology and Thermal Studies of Stearoyl Chitosan Varying the Degree of Substitution

Rheology and Thermal Studies of Stearoyl Chitosan Varying the Degree of Substitution

Physical, antibacterial and antioxidant properties of chitosan films incorporated with thyme oil for potential wound healing applications

Polymers in Oral Modified Release Systems

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