N-acetyltransferase 2, cytochrome P4502E1 and glutathione S-transferase genotypes in antitubercular treatment-induced hepatotoxicity in North Indians

Abstract

This study indicates that patients with slow-acetylator genotypes (NAT2 5/7, 6/7) and GSTM1 allele of GST enzyme were at higher risk of ATT-induced hepatotoxicity.

The association between the NAT2 genetic polymorphisms and risk of DILI during anti‐TB treatment: a systematic review and meta‐analysis

“… and Rana et al . were excluded due to overlap with their other studies (we therefore selected the later publication to analyse the distribution of the NAT2 genotype); three studies, by Guaoua et al . , Ng and Mishra et al .…”

“…The main characteristics of the 37 studies are shown in Table 1. The studies by An et al [15], Rana et al [16] and Rana et al [17] were excluded due to overlap with their other studies (we therefore selected the later publication to analyse the distribution of the NAT2 genotype); three studies, by Guaoua et al [18], Ng [19] and Mishra et al [20], were excluded as controls were not TB patients but healthy people; the studies by Roy et al [21] and Cavaco et al [22] were excluded due to the absence of complete NAT2 polymorphism distribution data. The study by Ohno et al [23] was excluded due to the absence of slow acetylators.…”

Update meta-analysis of theCYP2E1 RsaI/PstI andDraI polymorphisms and risk of antituberculosis drug-induced hepatotoxicity: evidence from 26 studies

“…As Huang et al . first reported that susceptibility to ATDH was associated with CYP2E1 genotypes, a number of association studies have been performed . However, these studies have yielded inconsistent results.…”

Polymorphism of PXR gene associated with the increased risk of drug-induced liver injury in Indonesian pulmonary tuberculosis patients

“…Many researchers have reported on specific gene polymorphisms as risk factors for those hepatotoxic effects. Some of the reported genes are N‐acetyltransferase 2 ( NAT2 ), cytochrome P450 2E1 ( CYP2E1 ), glutathione S‐transferase mu‐1 ( GSTM1 ) and glutathione S‐transferase theta ( GSTT ) . Other genes also reported to be potential predictors of ATDs‐DILI are pregnane X receptor ( PXR ), glutathione S‐transferase alpha‐1 ( GSTA1 ), manganese superoxide dismutase ( MnSOD , SOD2 ), UDP‐glucuronosyltransferase ( UGT ), nitric oxide synthase 2A ( NOS2A ), BTB and CNC homology 1 ( BACH1 ), Maf basic leucine zipper protein ( MAFK ), and human leucocyte antigen ( HLA ) …”