N-Acetylglucosamine Inhibits T-helper 1 (Th1)/T-helper 17 (Th17) Cell Responses and Treats Experimental Autoimmune Encephalomyelitis

Grigorian, Ani; Araujo, Lindsey; Naidu, Nandita N.; Place, Dylan J.; Choudhury, Biswa; Demetriou, Michael A.

doi:10.1074/jbc.m111.277814

Cited by 100 publications

(97 citation statements)

References 41 publications

(56 reference statements)

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“…Recently it was shown that the monosaccharide N-acetylglucosamine, a component of HA, effectively inhibited T-cell activation and ameliorated MOG induced C57BL/6 EAE. However, treatment is clinically ineffective if EAE is induced in 2D2 T-cell receptor transgenic mice, which display more robust disease (53). The severity of EAE disease is known to vary depending on the population of cellular infiltrates.…”

Section: Discussionmentioning

confidence: 99%

Hyaluronan Anchored to Activated CD44 on Central Nervous System Vascular Endothelial Cells Promotes Lymphocyte Extravasation in Experimental Autoimmune Encephalomyelitis

Winkler

Foster

Matsumoto

et al. 2012

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

Hyaluronan Anchored to Activated CD44 on Central Nervous System Vascular Endothelial Cells Promotes Lymphocyte Extravasation in Experimental Autoimmune Encephalomyelitis

Winkler

Foster

Matsumoto

et al. 2012

Journal of Biological Chemistry

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“…Ϫ/Ϫ Mice-GlcNAc supplementation in the drinking water of mice increases N-glycan branching on T cell receptors and regulates sensitivity to autoimmune antigens (49). Therefore, we tested whether GlcNAc in the drinking water (0.5 mg/ml) could increase Gcgr sensitivity.…”

Section: Glcnac Supplementation Rescues Sensitivity To Glucagon In Mgat5mentioning

confidence: 99%

N-Glycan Remodeling on Glucagon Receptor Is an Effector of Nutrient Sensing by the Hexosamine Biosynthesis Pathway

Johswich

Longuet

Pawling

et al. 2014

Journal of Biological Chemistry

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Background:The hexosamine biosynthesis pathway to UDP-GlcNAc has been implicated in glucose homeostasis. Results: UDP-GlcNAc and Golgi N-acetylglucosaminyltransferases modify the N-glycans on glucagon receptor, which increases sensitivity to glucagon in vivo. Conclusion: The hexosamine biosynthesis pathway contributes to glucose homeostasis, in part through N-glycan branching on glucagon receptor. Significance: Hepatic Mgat5 and the N-glycan branching pathway may be a therapeutic target for control of glycemia.

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“…They show potential reactions but do not reflect contributions of different sources to convergent pathways, cell and organ preferences, or allowance for metabolic states. Glycosylation disorders and models of these diseases are adding unexpected dimensions to the two-dimensional pathways (10,(37)(38)(39).…”

Section: Rediscovering Sugar Metabolismmentioning

confidence: 99%

Understanding Human Glycosylation Disorders: Biochemistry Leads the Charge

Freeze

2013

Journal of Biological Chemistry

193

141

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Nearly 70 inherited human glycosylation disorders span a breathtaking clinical spectrum, impacting nearly every organ system and launching a family-driven diagnostic odyssey. Advances in genetics, especially next generation sequencing, propelled discovery of many glycosylation disorders in single and multiple pathways. Interpretation of whole exome sequencing results, insights into pathological mechanisms, and possible therapies will hinge on biochemical analysis of patient-derived materials and animal models. Biochemical diagnostic markers and readouts offer a physiological context to confirm candidate genes. Recent discoveries suggest novel perspectives for textbook biochemistry and novel research opportunities. Basic science and patients are the immediate beneficiaries of this bidirectional collaboration.

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N-Acetylglucosamine Inhibits T-helper 1 (Th1)/T-helper 17 (Th17) Cell Responses and Treats Experimental Autoimmune Encephalomyelitis

Cited by 100 publications

References 41 publications

Hyaluronan Anchored to Activated CD44 on Central Nervous System Vascular Endothelial Cells Promotes Lymphocyte Extravasation in Experimental Autoimmune Encephalomyelitis

Hyaluronan Anchored to Activated CD44 on Central Nervous System Vascular Endothelial Cells Promotes Lymphocyte Extravasation in Experimental Autoimmune Encephalomyelitis

N-Glycan Remodeling on Glucagon Receptor Is an Effector of Nutrient Sensing by the Hexosamine Biosynthesis Pathway

Understanding Human Glycosylation Disorders: Biochemistry Leads the Charge

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