N-Acetyldopamine derivatives from Periostracum Cicadae and their regulatory activities on Th1 and Th17 cell differentiation

Antiepileptic Effects of Cicadae Periostracum on Mice and Its Antiapoptotic Effects in H2O2‐Stimulated PC12 Cells via Regulation of PI3K/Akt/Nrf2 Signaling Pathways

“…So, in our present study, we have also investigated the possible active substances in water extracts of CPM and found that the main components in CPM are acetyldopamine polymers and phenols, which is consistent with previous literatures [17]. Previous researches have revealed that acetyldopamine and its polymers in CPM possess promising antioxidant, antidiabetic, and anti-inflammatory activities and regulatory activities on Th1 and Th17 cell differentiation [8,9,36,37]. However, in an earlier study in 1991, it is reported that CPM also contains lots of microelements such as calcium (Ca), magnesium (Mg), and phosphorus (P), and the author thought these microelements might be also related to the anticonvulsant activities of CPM [38].…”

“…Increasing investigations have revealed that acetyldopamine polymers and phenols are the predominant phytochemical constituents in CPM [8]. In addition, modern pharmacological evidences suggest that this animal TCM possesses a wide spectrum of pharmacological activities, including antifebrile, spasmolytic, antiasthmatic, and antiphlogistic effects [8,9]. In the year of 2008, an experimental paper studied the effects of CPM on pentylenetetrazole-(PTZ-) induced mice and found that the water extracts of CPM had an antiepileptic activity [10].…”

(±)-Cryptamides A–D, Four Pairs of Novel Dopamine Enantiomer Trimers from the Periostracum Cicadae

“…PC has been used in traditional Chinese medicine for heat-clearing medicine within clinics [ 2 ]. Previously described pharmacological studies demonstrate anti-convulsion, anti-inflammatory, anti-tumor, antitussive, expectorant, anti-asthmatic, immune-suppressive, and anti-allergic properties of PC [ 3 , 4 , 5 , 6 ]. Previously reported chemical investigations have shown that the most common molecular components isolated from PC are N -acetyldopamine (NADA) derivatives [ 2 , 5 , 6 , 7 , 8 , 9 , 10 ].…”

“…Previously described pharmacological studies demonstrate anti-convulsion, anti-inflammatory, anti-tumor, antitussive, expectorant, anti-asthmatic, immune-suppressive, and anti-allergic properties of PC [ 3 , 4 , 5 , 6 ]. Previously reported chemical investigations have shown that the most common molecular components isolated from PC are N -acetyldopamine (NADA) derivatives [ 2 , 5 , 6 , 7 , 8 , 9 , 10 ]. At this point, it should be mentioned that most studies report findings of NADA dimers [ 2 , 5 , 6 , 8 , 9 , 10 , 11 ] and tetramers [ 12 ], while the discovery of trimers is unusual.…”

“…Previously reported chemical investigations have shown that the most common molecular components isolated from PC are N -acetyldopamine (NADA) derivatives [ 2 , 5 , 6 , 7 , 8 , 9 , 10 ]. At this point, it should be mentioned that most studies report findings of NADA dimers [ 2 , 5 , 6 , 8 , 9 , 10 , 11 ] and tetramers [ 12 ], while the discovery of trimers is unusual.…”