N-acetylcysteine relieves oxidative stress and protects hippocampus of rat from radiation-induced apoptosis by inhibiting caspase-3

Li, Jianguo; Zhang, Meng; Zhang, Guowei; Xing, Yonghua; Li, Feng; Fan, Saijun; Fan, Feiyue; Batu, Buren; Liu, Qiang

doi:10.1016/j.biopha.2014.12.029

Cited by 33 publications

(18 citation statements)

References 36 publications

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“…Caspase 3, which is one of these protease enzymes, has an important place in the apoptosis mechanism (Korsmeyer 1999;Hugle and Fulda 2015). It has been reported in some studies that there is a correlation between irradiation and caspase 3 expression (Ozyurt et al 2014;Li et al 2015;Ismail et al 2016). Li et al (2015) applied irradiation to the brains of rats and examined the effect of N-acetylcysteine (NAC).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported in some studies that there is a correlation between irradiation and caspase 3 expression (Ozyurt et al 2014;Li et al 2015;Ismail et al 2016). Li et al (2015) applied irradiation to the brains of rats and examined the effect of N-acetylcysteine (NAC). They determined that the caspase 3 level decreased in the NAC+ irradiation group, compared to the irradiation group.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, caspase 3 has an important place in the apoptosis mechanism (Korsmeyer 1999;Hugle and Fulda 2015). A correlation between irradiation and caspase 3 expression has been reported in some studies (Ozyurt et al 2014;Li et al 2015;Ismail et al 2016).…”

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confidence: 92%

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The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats

Özçelik

Erişir

Güler³

et al. 2018

Acta Vet. Brno

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The effect of irradiation on oxidants and antioxidants in selected tissues and a possible protective effect of curcumin on these indices were investigated. A total of 28 rats were divided into 3 groups; group 1 was control; group 2 was the irradiation group, saline was administered intraperiotenally (i.p.) for three days and then, 9 Gy gamma irradiation was applied; group 3 was the irradiation + curcumin group: curcumin was given i.p. for three days at 200 mg/kg body weight and then the same dose of irradiation was applied. A significant increase in malondialdehyde (MDA) was detected in the liver, kidney, and brain tissues of the rats as a result of irradiation (P < 0.01). Glutathione peroxidase (GSH-Px) activity in all the tissues (except for kidneys) decreased (P < 0.01), liver SOD (superoxide dismutase) activity decreased (P < 0.05), and GSH (glutathione) levels in kidney and ovary tissues (P < 0.001) significantly increased. While curcumin administration returned the increased MDA levels in the kidneys and brain in result of irradiation to normal (P < 0.01), it did not return the increased MDA levels in the liver tissue to normal (P < 0.001) despite significantly reducing them. While decreased GSH-Px and SOD activity in the liver in result of irradiation increased with the addition of curcumin (P < 0.05), increased GSH levels in the kidneys and ovaries returned to control levels (P < 0.001). When MDA values were examined, it was found that the addition of curcumin protected the liver, kidneys and brain from the oxidative damage caused by irradiation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats

Özçelik

Erişir

Güler³

et al. 2018

Acta Vet. Brno

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“…This agent works across a wide variety of tissues by scavenging free radicals and decreasing levels of caspase-3. 72 Treatment with n-acetylcysteine also improves wound healing 108 and anastomoses 26 after irradiation of rat models. These effects may be due to protection of immune cells following radiation.…”

Section: Resultsmentioning

confidence: 99%

Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight

McLaughlin¹,

Donoviel²,

Jones³

2017

Aerospace Medicine and Human Performance

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Background In the space environment, the traditional radioprotective principles of time, distance, and shielding become difficult to implement. Additionally, the complex radiation environment inherent in space, the chronic exposure timeframe, and the presence of numerous confounding variables complicate the process of creating appropriate risk models for astronaut exposure. Pharmaceutical options hold tremendous promise to attenuate acute and late effects of radiation exposure in the astronaut population. Pharmaceuticals currently approved for other indications may also offer radiation protection, modulation, or mitigation properties along with a well-established safety profile. Currently there are only three agents which have been clinically approved to be employed for radiation exposure, and these only for very narrow indications. This review identifies a number of agents currently approved by the U.S. Food and Drug Administration (FDA) which could warrant further investigation for use in astronauts. Specifically, we examine preclinical and clinical evidence for statins, nonsteroidal anti-inflammatory drugs (NSAIDs), angiotensin converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), metformin, calcium channel blockers, β adrenergic receptor blockers, fingolimod, N-acetylcysteine, and pentoxifylline as potential radiation countermeasures.

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“…For this, an antioxidant agent, N-acetylcysteine (NAC), was used to reduce cellular ROS levels [35, 36]. The effect of NAC on radiosensitivity was first examined.…”

Section: Resultsmentioning

confidence: 99%

GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathway

Chang

Lee

et al. 2016

Oncotarget

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Radiotherapy is an integral part for the treatment of head and neck cancer (HNC), while radioresistance is a major cause leads to treatment failure. GDF15, a member of the TGF-β superfamily, is hypothesized to participate in various types of homeostasis. However, the potential role of this molecule in regulation of radiosensitivity remains unclear. In this study, we demonstrated that GDF15 contributed to radioresistance of HNC, as determined by both gain- and lost-of-functional experiments. These results were achieved by the induction of mitochondrial membrane potential and suppression of intracellular reactive oxygen species (ROS). We further showed that GDF15 facilitated the conversion of cancer stemness, as assessed by the promotion of CD44+ and ALDH1+ cell populations and spheroid cell formation. At molecular level, GDF15 conferred to these cellular functions was through phosphorylated SMAD1 proteins to elite downstream signaling molecules. These cellular results were further confirmed in a tumor xenograft mouse study. Taken together, our results demonstrated that GDF15 contributed to radioresistance and cancer stemness by regulating cellular ROS levels via a SMAD-associated signaling pathway. GDF15 may serve as a prediction marker of radioresistance and a therapeutic target for the development of radio-sensitizing agents for the treatment of refractory HNC.

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N-acetylcysteine relieves oxidative stress and protects hippocampus of rat from radiation-induced apoptosis by inhibiting caspase-3

Cited by 33 publications

References 36 publications

The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats

The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats

Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight

GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathway

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