N‐acetylcysteine and ascorbic acid therapy for acute hepatic injury after hexavalent chromium ingestion

Yu, Jiun-Hao; Lu, Jian-Xun; Smollin, Craig G.; Cheng, Hao‐Tsai; Seak, Chen-June; Chen, Hsien-Yi

doi:10.1111/jcpt.13044

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…It has been reported that Cr(VI) can produce cellular oxidative stress and multi-organ system dysfunction including liver damage (Yu et al, 2020). Thus, we measured intracellular ROS formation in Cr(VI)-treated cells using ow cytometry.…”

Section: Cr(vi)-induced Acute Liver Injury Was Oxidative Stress-depen...mentioning

confidence: 99%

Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway

Tang

et al. 2022

Environ Sci Pollut Res

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Hexavalent chromium [Cr(VI)] is a serious environmental pollutant and threatens human health. Although it has been con rmed that oxidative stress is the main mechanism of liver injury caused by Cr(VI) exposure, the related toxic target and effective intervention measures have not been found. Clusterin (CLU) is an acute phase response protein with cytoprotective and apoptosis delaying effects, and its expression has been con rmed to increase signi cantly after exposure to Cr(VI). In this study, we demonstrate that CLU acts on the Protein Kinase B (PKB/Akt)-Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor E2-related factor 2 (Nrf2) signaling pathway to release Nrf2 into the nucleus. This to initiates the expression of a downstream protein, heme oxygenase 1 (HO-1), thereby attenuating the ubiquitination ability of Keap1 with Nrf2. We also demonstrated that CLU can affect oxidative stress through the Akt/Nrf2 pathway, which reduces the production of reactive oxygen species (ROS) induced by Cr(VI) and protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity. This study demonstrates a the mechanism of Cr(VI)-induced hepatotoxicity, and indicates that CLU as an intervention target of oxidative stress can provide valuable experimental basis for the prevention and treatment of occupational diseases in Cr(VI)-exposed population.

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Section: Cr(vi)-induced Acute Liver Injury Was Oxidative Stress-depen...mentioning

confidence: 99%

Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway

Tang

et al. 2022

Environ Sci Pollut Res

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“…Chromium has oxidation states from (II) to (VI) but is the most stable in its trivalent (III) [Cr(III)] and hexavalent (VI) [Cr(VI)] forms; however, Cr(VI) rarely occurs naturally and originates from anthropogenic sources. Unlike Cr(III), Cr(VI) is toxic and carcinogenic. , Excessive inhalation of Cr(VI) can lead to lung cancer, direct skin contact with it may result in dermatitis, and when ingested, it can cause organ damage . Cr(VI) compounds are, nonetheless, extremely important for electroplating, steel manufacturing, leather tanning, and textile production .…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Excessive inhalation of Cr(VI) can lead to lung cancer, 3 direct skin contact with it may result in dermatitis, 4 and when ingested, it can cause organ damage. 5 Cr(VI) compounds are, nonetheless, extremely important for electroplating, steel manufacturing, leather tanning, and textile production. 6 Inevitably, wastewater from these processes contains large amounts of Cr(VI), and unless properly treated, it can enter surface waters, causing harm to aquatic life and possibly entering the food chain.…”

Section: Introductionmentioning

confidence: 99%

Formation of Dense and High-Aspect-Ratio Iron Oxide Nanowires by Water Vapor-Assisted Thermal Oxidation and Their Cr(VI) Adsorption Properties

et al. 2021

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Coral-like and nanowire (NW) iron oxide nanostructures were produced at 700 and 800 °C, respectively, through thermal oxidation of iron foils in air- and water vapor-assisted conditions. Water vapor-assisted thermal oxidation at 800 °C for 2 h resulted in the formation of highly crystalline α-Fe2O3 NWs with good foil surface coverage, and we propose that their formation was due to a stress-driven surface diffusion mechanism. The Cr(VI) adsorption property of an aqueous solution on α-Fe2O3 NWs was also evaluated after a contact time of 90 min. The NWs had a removal efficiency of 97% in a 225 mg/L Cr(VI) solution (pH 2, 25 °C). The kinetic characteristic of the adsorption was fitted to a pseudo-second-order kinetic model, and isothermal studies indicated that the α-Fe2O3 NWs exhibited an adsorption capacity of 66.26 mg/g. We also investigated and postulated a mechanism of the Cr(VI) adsorption in an aqueous solution of α-Fe2O3 NWs.

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“…Chromium has oxidation states from (II) to (VI), but is most stable in its trivalent (III) [Cr(III)] and hexavalent (VI) [Cr(VI)] forms; however, Cr(VI) rarely occurs naturally and is typically manufactured. Unlike Cr(III), Cr(VI) is toxic and carcinogenic (Guertin et al 2016;Rahman and Singh 2019): excessive inhalation of Cr(VI) can lead to lung cancer (Lin et al 2019); direct skin contact with it may result in dermatitis (Lejding et al 2020); and when ingested, it can cause organ damage (Yu et al 2020). Cr(VI) compounds are, nonetheless, extremely important for electroplating, steel manufacturing, leather tanning, and textile production (Rosli et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Formation of Dense and High-Aspect-Ratio Iron Oxide Nanowires by Water-Vapor-Assisted Thermal Oxidation and their Cr(VI) Adsorption Properties

Budiman

Tan

Kawamura

et al. 2021

Preprint

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In this work, highly crystalline and high aspect ratio α-Fe2O3 nanowire (NWs) were successfully produced by thermal oxidation of iron in water vapor at 800°C. The process was done for 2 h and the NWs were found to be covering the foil uniformly unlike when the oxidation environment was dry whereby the NWs formed were shorted and rather dispersed. The formation of NWs was proposed to be due to a stress-driven surface diffusion during thermal oxidation process. When oxidation was done at 700 oC, we observed coral-like nanostructures. The α-Fe2O3 NWs were then used as adsorbent to remove Cr(VI) from stimulated wastewater. Removal efficiency of 97% in a 225 mg/L Cr(VI) solution was observed indicating very fast removal of Cr(VI) in the presence of the NWs. The kinetic characteristic of the adsorption was fitted to a pseudo-second-order kinetic model, and isothermal studies indicated that the α-Fe2O3 NWs exhibited an adsorption capacity of 66.26 mg/g.

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N‐acetylcysteine and ascorbic acid therapy for acute hepatic injury after hexavalent chromium ingestion

Cited by 7 publications

References 13 publications

Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway

Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway

Formation of Dense and High-Aspect-Ratio Iron Oxide Nanowires by Water Vapor-Assisted Thermal Oxidation and Their Cr(VI) Adsorption Properties

Formation of Dense and High-Aspect-Ratio Iron Oxide Nanowires by Water-Vapor-Assisted Thermal Oxidation and their Cr(VI) Adsorption Properties

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