N-Acetylcysteine Ameliorates Neurotoxic Effects of Manganese Intoxication in Rats: A Biochemical and Behavioral Study

Chopra, Devika; Sharma, Sheetal; Sharma, Neha; Nehru, Bimla

doi:10.1007/s11064-021-03312-2

Cited by 4 publications

(6 citation statements)

References 79 publications

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“…Mn treated with a dose of (25 mg/kg body weight) delivered i.p. had a shorter retention duration on the revolving rod than the control group (Chopra et al, 2021). Male Mn mice spent less time on the rota rod than control mice, according to Freeman et al (2020) the time spent on the rota rod by females after manganese exposure was not considerably reduced like that of the male.…”

Section: Effect Of Manganese Exposure In Neurobehavioural Alterationmentioning

confidence: 81%

“…Animals were also seen to have weak hind limbs, delayed motor initiative (akinesia), unsteady posture, and action tremor. Chopra et al (2021) revealed that on day 7, the open arm entries in the Mn-treated group in the elevated plus maze test were significantly lower than those in the control group.…”

Section: Effect Of Manganese Exposure In Neurobehavioural Alterationmentioning

confidence: 85%

“…Comparing rats treated with a dose of (25 mg/kg Mn) administered intraperitoneally once a day for two weeks to the control group, the passive avoidance test (PAT) revealed a substantial effect in memory impairment. (Chopra et al, 2021).…”

Section: Effect Of Manganese Exposure In Neurobehavioural Alterationmentioning

confidence: 99%

“…A hyperactive behaviour is highly suggested by this pattern of behavioural changes that includes increased activity, habituation flaws, decreased neophobia, and intense defecation. according to Chopra et al (2021) the total locomotory activity of the Mn-treated rats with a dose of (25 mg/kg body weight) delivered i.p. once daily for two weeks was significantly lower than that of the control group after day seven.…”

Section: Effect Of Manganese Exposure In Neurobehavioural Alterationmentioning

confidence: 99%

See 3 more Smart Citations

Cognitive, Sensory, and Motor Impairments Associated with Aluminium, Manganese, Mercury and Lead Exposures in the Onset of Neurodegeneration

Dike

Antia

Bababtunde

et al. 2023

IJPH

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Neurobehavioral investigations are essential for assessing the risk of heavy metal toxicity. This review provides a general overview of the cognitive and motor consequences associated with Al, Mn, Hg, and Pb exposure during early life as well as during adult stage in the onset of neurodegenerative diseases. This review showed that heavy metal exposure in early life results in more impacts due to the vulnerability of the blood brain barrier. The effects of Al, Mn, Hg, and Pb includes defects in habituation, decreased in rearing activity; intense defecation, motor impairments, decreased spatial memory and performance; declines in reference, recognition and working memory. It also causes an increase in the number of errors, an increase in the time it takes to find the platform, an increase in swimming distance, and a decrease in step-through latency and many others. Hence, Heavy metals are acknowledged inducers of behavioural toxicity and serve as sensitive endpoints of chemically produced neurotoxicity.

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Section: Effect Of Manganese Exposure In Neurobehavioural Alterationmentioning

confidence: 81%

Section: Effect Of Manganese Exposure In Neurobehavioural Alterationmentioning

confidence: 85%

Section: Effect Of Manganese Exposure In Neurobehavioural Alterationmentioning

confidence: 99%

Section: Effect Of Manganese Exposure In Neurobehavioural Alterationmentioning

confidence: 99%

See 2 more Smart Citations

Cognitive, Sensory, and Motor Impairments Associated with Aluminium, Manganese, Mercury and Lead Exposures in the Onset of Neurodegeneration

Dike

Antia

Bababtunde

et al. 2023

IJPH

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“…N -acetylcysteine (NAC), a precursor of GSH, effectively reduced Mn-induced oxidative damage and apoptosis in SH-SY5Y cells ( Stephenson et al, 2013 ). NAC also attenuated Mn-dysregulated GR and GPx levels in SH-SY5Y cells ( Maddirala et al, 2015 ) and increased SOD and CAT activities in the rat brain ( Chopra et al, 2021 ).…”

Section: Neurotherapeutics and Their Potential Underlying Mechanisms ...mentioning

confidence: 99%

Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

et al. 2022

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Chronic exposure to elevated levels of manganese via occupational or environmental settings causes a neurological disorder known as manganism, resembling the symptoms of Parkinson’s disease, such as motor deficits and cognitive impairment. Numerous studies have been conducted to characterize manganese’s neurotoxicity mechanisms in search of effective therapeutics, including natural and synthetic compounds to treat manganese toxicity. Several potential molecular targets of manganese toxicity at the epigenetic and transcriptional levels have been identified recently, which may contribute to develop more precise and effective gene therapies. This review updates findings on manganese-induced neurotoxicity mechanisms on intracellular insults such as oxidative stress, inflammation, excitotoxicity, and mitophagy, as well as transcriptional dysregulations involving Yin Yang 1, RE1-silencing transcription factor, transcription factor EB, and nuclear factor erythroid 2-related factor 2 that could be targets of manganese neurotoxicity therapies. This review also features intracellular proteins such as PTEN-inducible kinase 1, parkin, sirtuins, leucine-rich repeat kinase 2, and α-synuclein, which are associated with manganese-induced dysregulation of autophagy/mitophagy. In addition, newer therapeutic approaches to treat manganese’s neurotoxicity including natural and synthetic compounds modulating excitotoxicity, autophagy, and mitophagy, were reviewed. Taken together, in-depth mechanistic knowledge accompanied by advances in gene and drug delivery strategies will make significant progress in the development of reliable therapeutic interventions against manganese-induced neurotoxicity.

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N-acetylcysteine ameliorates chemotherapy-induced impaired anxiety and depression-like behaviors by regulating inflammation, oxidative and cholinergic status, and BDNF release

Aslanlar,

Vişneci,

et al. 2024

Behavioural Brain Research

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N-Acetylcysteine Ameliorates Neurotoxic Effects of Manganese Intoxication in Rats: A Biochemical and Behavioral Study

Cited by 4 publications

References 79 publications

Cognitive, Sensory, and Motor Impairments Associated with Aluminium, Manganese, Mercury and Lead Exposures in the Onset of Neurodegeneration

Cognitive, Sensory, and Motor Impairments Associated with Aluminium, Manganese, Mercury and Lead Exposures in the Onset of Neurodegeneration

Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

N-acetylcysteine ameliorates chemotherapy-induced impaired anxiety and depression-like behaviors by regulating inflammation, oxidative and cholinergic status, and BDNF release

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