N-Acetylchitooligosaccharide is a potent angiogenic inhibitor both in vivo and in vitro

Antiangiogenic activity of Tripterygium wilfordii and its terpenoids

“…Consistent with the notion, the effects of several antiagiogenic and proangiogenic agents found in zebrafish were also observed in mammalian systems (Parng et al, 2002;Cross et al, 2003;Seng et al, 2004). The use of zebrafish embryo to study antiangiogenic agents is increasingly reported (Belleri et al, 2005;Isenberg et al, 2007;Wang et al, 2007;Lam et al, 2008). Furthermore, angiogenic zebrafish model is suitable for high-throughput screening for antiangiogenic drugs with lower cost than mammalian models and offers greater relevance to humans as compared with in vitro cell lines and invertebrate models (Stern and Zon, 2003).…”

Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis

“…Angiogenesis involves the local proliferation of endothelial cells (Wang et al, 2007) and VEGF, a growth factor that stimulates HUVECs proliferation (Izuta et al, 2009). Therefore, we initially monitored the effect of PA extracts on VEGF-induced HUVECs proliferation.…”

Purification, characterization, and molecular cloning of an extracellular chitinase from Bacillus licheniformis stain LHH100 isolated from wastewater samples in Algeria

“…Thus, there have been many reports on cloning, expression and characterization of chitinases from various organisms, including bacteria, fungi, plant and animals [5]. Furthermore, chitinases are essential for the enzymatic production of (GlcNAc) n and GlcNAc, whose physiological roles are gaining increasing attention in recent research [6]. Accordingly, research on chitinases in various organisms should not only clarify these physiological roles, but should also be of use in the production of (GlcNAc) n and GlcNAc.…”