N-Acetyl-para-aminophenol as an Analgesic

Newton, Diane; Tanner, J. M.

doi:10.1136/bmj.2.5001.1096

Cited by 20 publications

(3 citation statements)

References 2 publications

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“…It was first marketed in the USA in 1950 and subsequently in the UK in 1956. Several studies in the 1950s established its efficacy in reducing fever (60) and relieving pain caused by cancer (61), dental surgery (62) or arthritis (63). Between 1957 and 2000, almost 100 clinical studies of the antipyretic action of acetaminophen, mostly in young children with various infections, many of the upper respiratory tract (64) were published.…”

Section: History Of Antipyretic Analgesicsmentioning

confidence: 99%

Antipyretic therapy

Botting¹

2004

Front Biosci

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Antipyresis can be achieved by physical methods such as cooling the body with tepid water or by pharmacological means such as the administration of antipyretic drugs. The nonsteroid anti-inflammatory drugs (NSAIDs) including aspirin, have been used to combat fever since the end of the 19th century and the analgesic antipyretics, from about the same time. Most of the antipyretic analgesics such as acetanilide and phenacetin are no longer used in therapy because of their toxicity. However, the metabolite of these two drugs, acetaminophen, became a highly popular antipyretic in the 1950s and is now the antipyretic of first choice in most developed countries. The disadvantages of administering NSAIDs is their gastrotoxicity manifested as irritation, ulcers and bleeding of the stomach mucosa. Acetaminophen also is toxic to the liver in doses only slightly above the therapeutic dose. Thus, selective COX-2 inhibitors, which do not damage the stomach and are free fom hepatotoxicity, may be the drugs of choice for reducing fever in the future.

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Section: History Of Antipyretic Analgesicsmentioning

confidence: 99%

Antipyretic therapy

Botting¹

2004

Front Biosci

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“…Of the few trials which have considered the possibility of non-homogeneous response, the first that I can recall was by Newton and Tanner (1956). Here the response was preference for one drug or another.…”

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confidence: 99%