N-acetyl-galactosamine modified metal-organic frameworks to inhibit the growth and pulmonary metastasis of liver cancer stem cells through targeted chemotherapy and starvation therapy

Hu, Jing; Hu, Jun; Wu, Wenrui; Qin, Yufei; Fu, Junjie; Zhou, Jingwen; Liu, Chao; Yin, Jian

doi:10.1016/j.actbio.2022.08.027

Cited by 14 publications

(7 citation statements)

References 42 publications

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“…Sor and GOx exerted reciprocal therapeutic effects and inhibited the growth and metastasis of liver tumour cells, thus achieving targeted dual-mode therapy with chemotherapy and starvation therapy for hepatocellular carcinoma (HCC). 98 In an in vitro assay, SG@GR-ZIF-8 showed significant anti-metastatic HCC activity against hepatocellular carcinoma stem cell-like cell line C5WN1 cells. In a mouse model carrying c5wn 1-tumours subcutaneously, SG@GR-ZIF-8 inhibited tumour growth by 89%.…”

Section: Ct/starvation Therapymentioning

confidence: 98%

Recent advances in Zn-MOFs and their derivatives for cancer therapeutic applications

Li,

Zhang,

et al. 2023

Mater. Adv.

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Section: Ct/starvation Therapymentioning

confidence: 98%

Recent advances in Zn-MOFs and their derivatives for cancer therapeutic applications

Li,

Zhang,

et al. 2023

Mater. Adv.

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“…Extrahepatic liver carcinoma metastasis usually spreads to the lungs. 102 Remodeling the metastatic TME is required for tumor metastases. Neutrophil-related metastatic TME results in the early disseminated colonization of tumor cells within the lungs.…”

Section: Distant Metastasismentioning

confidence: 99%

“…Extrahepatic liver carcinoma metastasis usually spreads to the lungs 102 . Remodeling the metastatic TME is required for tumor metastases.…”

Section: Netosis In Cancer Metastasismentioning

confidence: 99%

NETosis: Sculpting tumor metastasis and immunotherapy

Hu,

Wang,

Liu

2023

Immunological Reviews

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SummaryThe process of neutrophil extracellular traps (NETs) formation, called NETosis, is a peculiar death modality of neutrophils, which was first observed as an immune response against bacterial infection. However, recent work has revealed the unique biology of NETosis in facilitating tumor metastatic process. Neutrophil extracellular traps released by the tumor microenvironment (TME) shield tumor cells from cytotoxic immunity, leading to impaired tumor clearance. Besides, tumor cells tapped by NETs enable to travel through vessels and subsequently seed distant organs. Targeted ablation of NETosis has been proven to be beneficial in potentiating the efficacy of cancer immunotherapy in the metastatic settings. This review outlines the impact of NETosis at almost all stages of tumor metastasis. Furthermore, understanding the multifaceted interplay between NETosis and the TME components is crucial for supporting the rational development of highly effective combination immunotherapeutic strategies with anti‐NETosis for patients with metastatic disease.

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“…351 Nanoparticles loaded with sorafenib and glucose oxidase, designated SG@GR-ZIF-8, exhibited significant antimetastatic HCC activity. 352 The use of nanocarriers like mesoporous silica nanoparticles (MSNs) integrated with chemotherapy and immune checkpoint blocking therapy-termed as cocktail therapy demonstrated enhanced therapeutic efficacy against breast CSCs. It was reported to reduce the proportion of CSC and enhance the T cells infiltration in tumor tissues, and thus prolonged the survival of mice.…”

Section: Small Molecules and Antibodiesmentioning

confidence: 99%

“…Additionally, gold nanoparticles conjugated to doxorubicin (AuNPs‐Adr) effectively targeted and delivered doxorubicin to CSCs 351 . Nanoparticles loaded with sorafenib and glucose oxidase, designated SG@GR‐ZIF‐8, exhibited significant antimetastatic HCC activity 352 . The use of nanocarriers like mesoporous silica nanoparticles (MSNs) integrated with chemotherapy and immune checkpoint blocking therapy‐termed as cocktail therapy demonstrated enhanced therapeutic efficacy against breast CSCs.…”

Section: Targeting Csc Signaling Pathwaysmentioning

confidence: 99%

Cancer stem cells: Signaling pathways and therapeutic targeting

Talukdar,

Srivastava,

Sahoo

et al. 2023

MedComm – Oncology

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Cancer stem cells (CSCs) constitute a minority cell population characterized by unbounded proliferative potential in both solid and hematological cancers. Despite sharing key stem cell attributes, CSCs possess unique traits, including the initiation and propagation of tumors and resistance to conventional therapies. The purpose of this review is to delve into the origins and fundamental characteristics of CSCs, emphasizing their role in tumor growth and metastasis. The focus extends to unraveling cellular signaling pathways driving oncogenic processes and understanding aberrant cellular crosstalk crucial for targeted cancer therapies. Beginning with an exploration of CSC properties and behavior, we progress to dissecting the cellular signaling network that fuels oncogenic pathways. The discussion spans the inception of CSCs, their survival strategies, and adaptation to new environments. We then transit to recent therapeutic advancements targeting CSCs, culminating in an exploration for precise therapeutic targeting. This review henceforth, underscores the vital significance of comprehending CSCs in cancer progression and treatment resistance. By unraveling the complex signaling pathways and survival mechanisms unique to CSCs, it paves the way for targeted therapeutic strategies that hold immense promise in enhancing cancer treatment efficacy while minimizing collateral damage.

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N-acetyl-galactosamine modified metal-organic frameworks to inhibit the growth and pulmonary metastasis of liver cancer stem cells through targeted chemotherapy and starvation therapy

Cited by 14 publications

References 42 publications

Recent advances in Zn-MOFs and their derivatives for cancer therapeutic applications

Recent advances in Zn-MOFs and their derivatives for cancer therapeutic applications

NETosis: Sculpting tumor metastasis and immunotherapy

Cancer stem cells: Signaling pathways and therapeutic targeting

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