n-3 Fatty acids and ventricular arrhythmias in patients with ischaemic heart disease and implantable cardioverter defibrillators

Christensen, Jeppe Hagstrup; Riahi, Sam; Schmidt, Erik Berg; Mølgaard, Henning; Pedersen, Anders Kirstein; Heath, Finn; Nielsen, Jens Cosedis; Toft, Egon

doi:10.1016/j.eupc.2005.02.118

Cited by 41 publications

(20 citation statements)

References 36 publications

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“…For three of the ten patients, VT could not be induced even at baseline and, interestingly, these patients had a higher mean plasma phospholipid omega-3 FA content than those with inducible arrhythmia (6.2% vs 4.8%). The same inverse relationship between FA content and incidence of malignant ventricular arrhythmias was demonstrated by Christensen et al [21] in 98 patients with ischemic heart disease and implantable cardioverter defibrillators (ICDs). During 1-year follow-up, those with the lowest level of omega-3 FAs in serum phospholipids (mean, 5.5%) had more ventricular arrhythmias than those with the highest concentrations (mean, 13.0%).…”

Section: Human Evidence For An Anti-arrhythmic Effect Of Omega-3 Fassupporting

confidence: 54%

Omega-3 fatty acids, acute coronary syndrome, and sudden death

Harris

Schacky²

2008

Curr Cardio Risk Rep

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Section: Human Evidence For An Anti-arrhythmic Effect Of Omega-3 Fassupporting

confidence: 54%

Omega-3 fatty acids, acute coronary syndrome, and sudden death

Harris

Schacky²

2008

Curr Cardio Risk Rep

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“…n-3 PUFAs have been associated with decreased risk of ventricular arrhythmias (4,5) and sudden cardiac death (SCD) (6). Some authors have suggested that the beneficial impact on SCD could be mediated by enhancing the heart rate variability (HRV), which represents the sympathetic and parasympathetic activities of the autonomic nervous system (ANS).…”

Section: Introductionmentioning

confidence: 99%

Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults

Valera¹,

Dewailly

Anassour-Laouan-Sidi³

et al. 2011

International Journal of Circumpolar Health

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Objectives. Inuit from Nunavik (northern Quebec) consume large amounts of fish and marine mammals, which are important sources of n-3 polyunsaturated fatty acids (n-3 PUFAs). These substances have a beneficial impact on heart rate (HR) and heart rate variability (HRV). However, it is unknown if this beneficial impact remains significant in populations with high mercury exposure. The study assessed the impact of n-3 PUFAs (Docosahexaenoic [DHA] and Eicosapentaenoic acid [EPA]) on resting HR and HRV among Nunavik Inuit adults considering mercury and other potential confounders. Study design. Cross-sectional study employing clinical measurements. Methods. Complete data were collected among 181 adults ≥40 years old (109 women and 72 men) living in the 14 coastal villages of Nunavik. Several indices of HRV were derived from a 2-hour Holter monitoring assessment. n-3 PUFAs levels were measured in membrane erythrocytes. Simple linear regression was used to analyse the relationship between n-3 PUFAs levels and resting HR and HRV parameters while multiple linear regressions were carried out to control for confounders. Results. In the overall analyses, EPA was associated with SDANN (β=0.07, p=0.04) and LF norm (β=-1.84, p=0.03) after adjusting for confounders. Among women, DHA was associated with resting HR (β=-1.40, p=0.03) while EPA was associated with SDNN (β=0.08, p=0.03), SDANN (β=0.09, p=0.02) and resting HR (β=-2.61, p=0.002). No significant association was observed in men. Conclusions. These results suggest a beneficial impact of n-3 PUFAs on resting HR and HRV among Nunavik Inuit women.

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“…In an observational study by Christensen et al, 98 patients with CAD who had ICDs gave blood for analysis of n-3 PUFA concentrations, and the prevalence of appropriate ICD therapy in the preceding 12 months was analyzed. 80 Investigators found that patients with multiple VT/VF events had lower n-3 PUFA levels than patients with no events (mean 7.1% vs. 9.2%, P Ͻ 0.01). Those in the lowest quintiles of n-3 PUFA levels had significantly more VT/VF events than those in the highest quintile (mean 1.3 events vs. 0.2 events, P Ͻ 0.05).…”

Section: Effect Of N-3 Pufas In Patients With Implantable Cardiovertementioning

confidence: 93%

Effects of Lipid-Altering Therapies on Ventricular Arrhythmias and Sudden Cardiac Death

Majmudar

Tompkins

Bachmann

et al. 2009

Cardiology in Review

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Sudden cardiac death remains a leading cause of mortality in the United States, with an incidence of 300,000 to 400,000 deaths annually. Despite advances in the management of cardiovascular disease, the only effective treatments proven to reduce the risk of sudden cardiac death are beta-adrenergic blockers and implantable cardioverter-defibrillators. Antiarrhythmic medications are effective at treating symptomatic and asymptomatic ventricular arrhythmias, but several are associated with increased mortality. Although effective at lowering mortality, implantable cardioverter-defibrillators pose an economic burden and some morbidity to patients when associated with frequent shock therapies. Thus, there is renewed interest in developing additional pharmacologic alternatives that could reduce the risk of fatal ventricular arrhythmias. A post hoc analysis of 2 large clinical trials suggested an association between the use of lipid-altering therapy and decreased rates of sudden death. Retrospective review of other clinical trials and experimental data using animal models provide further insight into the potential antiarrhythmic properties of lipid-altering therapy. This review examines the current status of basic science and clinical research that explores the antiarrhythmic properties of lipid-altering therapy, with a focus on 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) and polyunsaturated fatty acids.

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n-3 Fatty acids and ventricular arrhythmias in patients with ischaemic heart disease and implantable cardioverter defibrillators

Cited by 41 publications

References 36 publications

Omega-3 fatty acids, acute coronary syndrome, and sudden death

Omega-3 fatty acids, acute coronary syndrome, and sudden death

Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults

Effects of Lipid-Altering Therapies on Ventricular Arrhythmias and Sudden Cardiac Death

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