n-3 fatty acid-based parenteral nutrition improves postoperative recovery for cirrhotic patients with liver cancer: A randomized controlled clinical trial

Zhang, Binhao; Wei, Gang; Li, Rui; Wang, Yanjun; Yu, Jie; Wang, Rui; Xiao, Hua; Wu, Chao; Leng, Chao; Chen, Xiaoping

doi:10.1016/j.clnu.2016.08.002

Cited by 43 publications

(72 citation statements)

References 25 publications

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“…The average number of patients per study was 101 (range 35–320). Four studies [ 13 , 17 – 19 ] performed per-protocol analysis and one [ 14 ] conducted intention-to-treat analysis. Standard criteria for inclusion and exclusion were defined in all included studies.…”

Section: Resultsmentioning

confidence: 99%

“…Standard criteria for inclusion and exclusion were defined in all included studies. Two studies [ 13 , 19 ] reported 30-day evaluations after surgery and three [ 14 , 15 , 17 ] described 6-month follow-up.…”

Section: Resultsmentioning

confidence: 99%

“…Timing, duration, type, and dosage of immunonutrition varied between studies. Immunonutrition was given preoperatively for a minimum of 5 days in 2 studies [ 14 , 18 ], postoperatively for 5–7 days in 5 studies [ 12 , 13 , 15 – 17 ], and perioperatively in 1 study [ 19 ]. Postoperative supplementation altered from the day after surgery to the day of hemodynamic stability.…”

Section: Resultsmentioning

confidence: 99%

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The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis

et al. 2017

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Perioperative immunonutrition in liver resection remains doubtful. A systematic review and meta-analysis was conducted to compare postoperative outcomes between patients undergoing hepatectomy who received perioperative immunonutrition and those who did not.A PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Knowledge database search was performed to retrieve all of the randomized controlled trials (RCTs) evaluating the value of perioperative immunonutrition in patients undergoing hepatectomy until the end of September 2016. Data extraction and quality assessment of RCTs were performed in accordance with PRISMA guidelines. The quality of evidence for each postoperative outcome was assessed using the GRADEpro analysis. A random-effects model was used to conduct a meta-analysis with RevMan 5.3.5 software. Eight RCTs including 805 patients (402 with and 403 without immunonutrition) were identified. Immunonutrition, mainly ω-3 fatty acids, significantly reduced the incidence of postoperative total complications (risk ratio [RR] = 0.59; 95% confidence interval [CI], 0.46–0.75; p < 0.0001) and infectious complications (RR = 0.46; 95% CI, 0.32–0.68; p < 0.0001), and shortened the length of hospital stay (standardized mean difference, −0.49; 95% CI, −0.81 to −0.16; p = 0.0004). There was no significant between-group difference in postoperative mortality (RR = 0.46; 95% CI, 0.16–1.31; p = 0.15). Immunonutrition, mainly ω-3 fatty acids, is potentially beneficial in reducing overall and infectious postoperative complications and in shortening the hospital stay for patients undergoing hepatectomy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis

et al. 2017

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“…One prospective randomized controlled study showed that ω-3 PUFAs could signi cantly ameliorate the postoperative in ammatory response in 48 patients with gastric cancer 29 . Zhang et al 30 found that ω-3 PUFA-supplemented PN could improve postoperative recovery, reduced postoperative complications, and shorten hospital stays after hepatectomy in patients with liver cirrhosis or liver cancer. A meta-analysis by Zhao et al 31 revealed that early application of ω-3 PUFAs in patients with gastrointestinal cancer could improve immunity, reduce the postoperative stress response, and attenuate metastasis or recurrence.…”

Section: Discussionmentioning

confidence: 99%

Effects of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on postoperative complications for patients with Crohn’s disease: a cohort study

Liu

et al. 2020

Preprint

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Background: Most patients with Crohn's disease (CD), a chronic inflammatory disease, need surgery but exhibit elevated postoperative complication incidences. ω-3 polyunsaturated fatty acids (PUFAs) are considered beneficial for nutrition, anti-inflammation, immunity and intestinal microflora balance in humans. This study assessed the effects of ω-3 PUFA-supplemented parenteral nutrition (PN) on postoperative complications in CD.Methods: Overall, 186 CD patients undergoing bowel resection were eligible. Patient data were collected from a prospectively maintained database. After surgery, 103 patients received ω-3 PUFA-supplemented PN; 83 did not. Postoperative complications were compared between the groups. Complication risk factors were identified by univariate and multivariate analyses.Results: Patients with ω-3 PUFA-supplemented PN after surgery had lower C-reactive protein levels (57.2±5.3 mg/L vs 43.5±3.9 mg/L, P=0.047) and shorter postoperative hospital stays (12.1±1.1 days vs 9.3±0.6 days, P=0.041) than those without. The ω-3 PUFA group exhibited significantly reduced incidences of overall complications (40.8% vs 24.1%, P=0.016) and major complications (23.3% vs 9.6%, P=0.014). Postoperative complications were associated with infliximab, ω-3 PUFAs, C-reactive protein, operative time, and laparoscopic surgery. Multivariate regression revealed that preoperative infliximab use and postoperative ω-3 PUFA-supplemented PN were independent risk factors in CD. Conclusions: ω-3 PUFA-supplemented PN reduced post-surgery inflammatory response in CD patients, thus decreasing postoperative complications and accelerating recovery.Trial registration: This trial was registered in ClinicalTrials.gov. Identifier was NCT03901937. The date of registration was 03/04/2019.

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“…In the case of non-melanoma skin cancer, grape seed proanthocyanidins have exhibited significant inhibition of the growth of skin tumors in animal models through the promotion of damaged DNA repair and the stimulation of the immune system, a mechanism that holds promise for the prevention of excessive exposure to solar UVB radiation and the reduction of the risk of nonmelanoma skin cancer in humans [46]. Finally, reductions in overall mortality and length of hospital stay in cirrhotic patients with liver cancer recovering from surgery were observed to be significantly improved upon dietary supplementation of n-3 fatty acid [47].…”

Section: Nutrition and Cancer Riskmentioning

confidence: 99%

Nutrition, Cancer Genetics and Epigenetics

Lundström¹

2019

obm genet

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Epidemiological data and meta-analysis have confirmed that there exists a strong association between nutrition and disease risk. In the context of cancer, it has been demonstrated that unhealthy diets increase the risk of disease. On the other hand, major dietary interventions and lifestyle changes have been demonstrated to provide therapeutic efficacy in cancer patients. Genetic mechanisms have been reported to be associated with cancer development induced by environmental and nutritional factors. Genetics plays an important role in the designing of personalized drugs and diets. Epigenetics has also been demonstrated to be affected by nutrition, leading to increased risk of disease when unhealthy diets are consumed, while healthy nutrition is able to provide both prophylactic and therapeutic efficacy.

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n-3 fatty acid-based parenteral nutrition improves postoperative recovery for cirrhotic patients with liver cancer: A randomized controlled clinical trial

Cited by 43 publications

References 25 publications

The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis

The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis

Effects of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on postoperative complications for patients with Crohn’s disease: a cohort study

Nutrition, Cancer Genetics and Epigenetics

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