N-(2-ozoazepan-3-yl)-pyrrolidine-2-carboxamide, a novel Octopus vulgaris ink-derived metabolite, exhibits a pro-apoptotic effect on A549 cancer cell line and inhibits pro-inflammatory markers

Hernández-Zazueta, Martín Samuel; García-Romo, Joel Said; Luzardo-Ocampo, Iván; Taboada-Antelo, Pablo; Rosas‐Burgos, Ema Carina; Ezquerra‐Brauer, Josafat Marina; Martínez-Soto, Juan Manuel; Plata, María del Carmen Candía; Santacruz‐Ortega, Hisila; Burgos‐Hernández, Armando

doi:10.1016/j.fct.2023.113829

Cited by 3 publications

(6 citation statements)

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“…Furthermore, from the Octopus vulgaris ink extracts, an antiproliferative and proapoptotic activity was observed for a metabolite called N-(2-ozoazepa-n3-yl)-pyrrolidine-2-carboxamide, known as Ozopromide (OPC). This novel metabolite derived from Octopus vulgaris ink demonstrates proapoptotic effects on A549 lung cancer cells and inhibits pro-inflammatory markers [87]. Specifically, antiproliferative activity has been also observed in cell lines of certain cancer types such as prostate (22Rv1), lung (A549), and cervical epithelioid adenocarcinoma (HeLa) [88].…”

Section: Analysis Of the Foods And Keymentioning

confidence: 90%

“…Specifically, antiproliferative activity has been also observed in cell lines of certain cancer types such as prostate (22Rv1), lung (A549), and cervical epithelioid adenocarcinoma (HeLa) [88]. Additionally, Octopus vulgaris extracts containing OPC have shown anti-inflammatory activity in LPS-stimulated RAW 264.7 cells, highlighting the potential of Octopus vulgaris ink as a nutraceutical product or supplement with antitumoral action [87].…”

Section: Analysis Of the Foods And Keymentioning

confidence: 96%

“…ditionally, Octopus vulgaris extracts containing OPC have shown anti-inflammatory activity in LPS-stimulated RAW 264.7 cells, highlighting the potential of Octopus vulgaris ink as a nutraceutical product or supplement with antitumoral action [87].…”

Section: Analysis Of the Foods And Keymentioning

confidence: 98%

“…In silico ADMET prediction studies suggested a lower potential for acute toxicity for OPC after oral administration, although further studies are needed to confirm this. Continued research is necessary to investigate the effects of OPC in in vitro and in vivo models of cancer and inflammation [87].…”

Section: Analysis Of the Foods And Keymentioning

confidence: 99%

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The Southern European Atlantic Diet and Its Supplements: The Chemical Bases of Its Anticancer Properties

Vivanco,

Taboada,

Coelho

2023

Nutrients

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Scientific evidence increasingly supports the strong link between diet and health, acknowledging that a well-balanced diet plays a crucial role in preventing chronic diseases such as obesity, diabetes, cardiovascular issues, and certain types of cancer. This perspective opens the door to developing precision diets, particularly tailored for individuals at risk of developing cancer. It encompasses a vast research area and involves the study of an expanding array of compounds with multilevel “omics” compositions, including genomics, transcriptomics, proteomics, epigenomics, miRNomics, and metabolomics. We review here the components of the Southern European Atlantic Diet (SEAD) from both a chemical and pharmacological standpoint. The information sources consulted, complemented by crystallographic data from the Protein Data Bank, establish a direct link between the SEAD and its anticancer properties. The data collected strongly suggest that SEAD offers an exceptionally healthy profile, particularly due to the presence of beneficial biomolecules in its foods. The inclusion of olive oil and paprika in this diet provides numerous health benefits, and scientific evidence supports the anticancer properties of dietary supplements with biomolecules sourced from vegetables of the brassica genus. Nonetheless, further research is warranted in this field to gain deeper insights into the potential benefits of the SEAD’s bioactive compounds against cancer.

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Section: Analysis Of the Foods And Keymentioning

confidence: 90%

Section: Analysis Of the Foods And Keymentioning

confidence: 96%

Section: Analysis Of the Foods And Keymentioning

confidence: 98%

Section: Analysis Of the Foods And Keymentioning

confidence: 99%

See 2 more Smart Citations

The Southern European Atlantic Diet and Its Supplements: The Chemical Bases of Its Anticancer Properties

Vivanco,

Taboada,

Coelho

2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…[65] 2. interfering with G1/S cell cycle arrest. [66] The anticancer potential of marine tunicates Ascidiella aspersa and Styela clava collected from the Aegean Sea was studied. The cytotoxic activity of their methanolic extracts was tested on AGS, PC-3, SH-SY5Y, and L929 cell lines.…”

Section: Zhang Et Al Isolated Compounds Varioloid a And Varioloid B Frommentioning

confidence: 99%

Using nanotechnology to progress the utilization of marine natural products in combating multidrug resistance in cancer: A prospective strategy

Bhusare,

Gade,

Kumar

2024

J Biochem & Molecular Tox

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Achieving targeted, customized, and combination therapies with clarity of the involved molecular pathways is crucial in the treatment as well as overcoming multidrug resistance (MDR) in cancer. Nanotechnology has emerged as an innovative and promising approach to address the problem of drug resistance. Developing nano‐formulation‐based therapies using therapeutic agents poses a synergistic effect to overcome MDR in cancer. In this review, we aimed to highlight the important pathways involved in the progression of MDR in cancer mediated through nanotechnology‐based approaches that have been employed to circumvent them in recent years. Here, we also discussed the potential use of marine metabolites to treat MDR in cancer, utilizing active drug‐targeting nanomedicine‐based techniques to enhance selective drug accumulation in cancer cells. The discussion also provides future insights for developing complex targeted, multistage responsive nanomedical drug delivery systems for effective cancer treatments. We propose more combinational studies and their validation for the possible marine‐based nanoformulations for future development.

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Southern European Atlantic Diet and Its Supplements: Chemical Bases of Its Anticancer Properties

Vivanco,

Taboada,

Coelho

2023

Preprint

View full text Add to dashboard Cite

Scientific evidence increasingly supports the strong link between diet and health, acknowledging that a well-balanced diet plays a crucial role in preventing chronic diseases such as obesity, diabetes, cardiovascular issues, and certain types of cancer. This perspective opens the door to developing precision diets, particularly tailored for individuals at risk of developing cancer. It encompasses a vast research area and involves the study of an expanding array of compounds with multi-level "omics" compositions, including genomics, transcriptomics, proteomics, epigenomics, miRNomics, and metabolomics. We review here the components of the Southern European Atlantic Diet (SEAD) from both a chemical and pharmacological standpoint. The information sources consulted, complemented by crystallographic data from the Protein Data Bank, establish a direct link between SEAD and its anticancer properties. The data collected strongly suggest that SEAD offers an exceptionally healthy profile, particularly due to the presence of beneficial biomolecules in its foods. The inclusion of olive oil and paprika in this diet provides numerous health benefits, and science supports the anti-cancer properties of dietary supplements with biomolecules sourced from vegetables of the brassica genus. Nonetheless, further research is warranted in this field to gain deeper insights into the potential benefits of SEAD's bioactive compounds against cancer.

show abstract

N-(2-ozoazepan-3-yl)-pyrrolidine-2-carboxamide, a novel Octopus vulgaris ink-derived metabolite, exhibits a pro-apoptotic effect on A549 cancer cell line and inhibits pro-inflammatory markers

Cited by 3 publications

References 48 publications

The Southern European Atlantic Diet and Its Supplements: The Chemical Bases of Its Anticancer Properties

The Southern European Atlantic Diet and Its Supplements: The Chemical Bases of Its Anticancer Properties

Using nanotechnology to progress the utilization of marine natural products in combating multidrug resistance in cancer: A prospective strategy

Southern European Atlantic Diet and Its Supplements: Chemical Bases of Its Anticancer Properties

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