N-(2-Benzoyl-4,5-dimethoxyphenethyl)-2-phenylacetamide

Marinova, Petja; Nikolova, Stoyanka; Dołęga, Anna; Ahmedova, Anife

doi:10.3390/m1376

Cited by 1 publication

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“…A series of metal complexes of α-ketoamide were synthesized and their composition and structure with palladium was studied [21,22]. Recently, we presented the synthesis and characterization of a new Pd(II) and Zn(II) complexes of N-substituted-4,5-dimethoxyphenylethyl-2-arylketoamides [23], as well as the crystal structure of N-(2-benzoyl-4,5-dimethoxyphenethyl)-2phenylacetamide [24].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of N-[1-(2-Acetyl-4,5-dimethoxyphenyl)propan-2-yl]benzamide and Its Copper(II) Complex

2023

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This paper represents a convenient method for the synthesis of N- [1-(2-acetyl-4,5-dimethoxyphenyl)propan-2-yl]benzamide and its Cu(II) complex. In silico analysis predicted spasmolytic activity for the compound. Based on the in silico calculations, the importance of the predicted ketoamide, and our previous experiments, we synthesized the ketoamide via ortho-acylation of N- [1-(3,4-dimethoxyphenyl)propan-2-yl]benzamide with acetic anhydride in polyphosphoric acid. We applied the title ketoamide in reaction with Cu(II) varying the solvents. We found that the reaction leads to the formation of a coordination compound when the ligand dissolved in DMSO reacts with a water solution of CuCl 2 in an alkaline environment in a molar ratio M : L : OH -= 1 : 2 : 2. The structures of the new compounds are discussed based on their melting points, IR, 1 H, 13 C NMR and Raman spectral data.

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Section: Introductionmentioning

confidence: 99%